Narrow endopeptidase specificity. Cleaves Pro-Leu-Ala-Gln-Ala-|-Val-Arg-Ser-Ser-Ser in the membrane-bound, 26-kDa form of tumor necrosis factor alpha (TNFalpha). Similarly cleaves other membrane-anchored, cell-surface proteins to "shed" the extracellular
BiSSCat v1.06.20http://bisscat.org/ Developed by Masaaki Kotera, Department of Biochemistry, Trinity College Dublin. Science Foundation of Ireland is gratefully acknowledged.