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Home Help FGROUP SUBSTRUCTURE compound enzyme Multiple

EC 2.1.1.45 thymidylate synthase

IUBMB ExplorEnz BRENDA KEGG ExPASy ERGO

Equation(s) (IUBMB)

5,10-methylenetetrahydrofolate + dUMP = dihydrofolate + dTMP

Reaction(s) (KEGG)

R02237 [Fig]ATP + 7,8-Dihydropteroate + L-Glutamate <=>ADP + Orthophosphate + 7,8-Dihydrofolate
R02101 [Fig]2'-Deoxyuridine 5'-phosphate + 5,10-Methylene-THF <=>7,8-Dihydrofolate + 5'-Thymidylic acid

Inhibitor(s)

5-fluorodeoxyuridine monophosphate
BiSSCat v1.06.20 http://bisscat.org/
Developed by Masaaki Kotera, Department of Biochemistry, Trinity College Dublin.
Science Foundation of Ireland is gratefully acknowledged.