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Home Help FGROUP SUBSTRUCTURE compound enzyme Multiple

EC 1.2.4.2 oxoglutarate dehydrogenase (succinyl-transferring)

IUBMB ExplorEnz BRENDA KEGG ExPASy ERGO

Equation(s) (IUBMB)

2-oxoglutarate + lipoyllysine = S-succinyldihydrolipoyllysine + CO2

Reaction(s) (KEGG)

R01933 [Fig]2-Oxoadipate + CoA + NAD+ <=>Glutaryl-CoA + CO2 + NADH + H+
R00621 [Fig]2-Ketoglutaric acid + Thiamine diphosphate <=>3-Carboxy-1-hydroxypropyl-ThPP + CO2
R03316 [Fig]3-Carboxy-1-hydroxypropyl-ThPP + Lipoamide <=>S-Succinyldihydrolipoamide + Thiamine diphosphate
R01940 [Fig]2-Oxoadipate + Lipoamide <=>S-Glutaryldihydrolipoamide + CO2
R01700 [Fig]2-Ketoglutaric acid + Lipoamide <=>S-Succinyldihydrolipoamide + CO2

Cofactor(s)

Thiamine diphosphate
BiSSCat v1.06.20 http://bisscat.org/
Developed by Masaaki Kotera, Department of Biochemistry, Trinity College Dublin.
Science Foundation of Ireland is gratefully acknowledged.