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Home Help FGROUP SUBSTRUCTURE compound enzyme Multiple

EC 1.2.4.1 pyruvate dehydrogenase (acetyl-transferring)

IUBMB ExplorEnz BRENDA KEGG ExPASy ERGO

Equation(s) (IUBMB)

pyruvate + lipoyllysine = S-acetyldihydrolipoyllysine + CO2

Reaction(s) (KEGG)

R03270 [Fig]2-(alpha-Hydroxyethyl)thiamine diphosphate + Lipoamide <=>6-S-Acetyldihydrolipoamide + Thiamine diphosphate
R00209 [Fig]2-Oxopropanoate + CoA + NAD+ <=>Acetyl-CoA + CO2 + NADH
R01699 [Fig]2-Oxopropanoate + Lipoamide <=>6-S-Acetyldihydrolipoamide + CO2
R00014 [Fig]2-(alpha-Hydroxyethyl)thiamine diphosphate + CO2 <=>Thiamine diphosphate + 2-Oxopropanoate
R00210 [Fig]2-Oxopropanoate + CoA + NADP+ <=>Acetyl-CoA + CO2 + NADPH

Cofactor(s)

Thiamine diphosphate
BiSSCat v1.06.20 http://bisscat.org/
Developed by Masaaki Kotera, Department of Biochemistry, Trinity College Dublin.
Science Foundation of Ireland is gratefully acknowledged.