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Home Help FGROUP SUBSTRUCTURE compound enzyme Multiple

EC 1.14.99.1 prostaglandin-endoperoxide synthase

IUBMB ExplorEnz BRENDA KEGG ExPASy ERGO

Equation(s) (IUBMB)

arachidonate + AH2 + 2 O2 = prostaglandin H2 + A + H2O

Reaction(s) (KEGG)

R01590 [Fig](5Z,8Z,11Z,14Z)-Icosatetraenoic acid + 2 O2 <=>PGG2
R01599 [Fig](5Z,8Z,11Z,14Z)-Icosatetraenoic acid + Reduced acceptor + 2 O2 <=>(5Z,13E)-(15S)-9alpha,11alpha-Epidioxy-15-hydroxyprosta-5,13- dienoate + Acceptor + H2O
R00073 [Fig]2 (5Z,13E)-(15S)-9alpha,11alpha-Epidioxy-15-hydroxyprosta-5,13- dienoate + O2 <=>2 PGG2

Inhibitor(s)

2-Acetoxybenzenecarboxylic acid
Naprosyn
Clinoril
Advil
Feldene
Diclofenac
Diflunisal
Ketoprofen
Indocin
Mefenamic acid
Tolectin
Fenprofen calcium
Meclofenamate sodium
BiSSCat v1.06.20 http://bisscat.org/
Developed by Masaaki Kotera, Department of Biochemistry, Trinity College Dublin.
Science Foundation of Ireland is gratefully acknowledged.