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Home Help FGROUP SUBSTRUCTURE compound enzyme Multiple

EC 1.14.15.6 cholesterol monooxygenase (side-chain-cleaving)

IUBMB ExplorEnz BRENDA KEGG ExPASy ERGO

Equation(s) (IUBMB)

cholesterol + reduced adrenal ferredoxin + O2 = pregnenolone + 4-methylpentanal + oxidized adrenal ferredoxin + H2O

Reaction(s) (KEGG)

R04676 [Fig]17alpha,20alpha-Dihydroxycholesterol + NADPH + H+ + O2 <=>17alpha-Hydroxypregnenolone + 4-Methylpentanal + NADP+ + H2O
R04854 [Fig]20alpha-Hydroxycholesterol + NADPH + H+ + O2 <=>(22R)-20alpha,22-Dihydroxycholesterol + NADP+ + H2O
R04855 [Fig]22beta-Hydroxycholesterol + NADPH + H+ + O2 <=>(22R)-20alpha,22-Dihydroxycholesterol + NADP+ + H2O
R02723 [Fig]Cholesterol + NADPH + O2 <=>22beta-Hydroxycholesterol + NADP+ + H2O
R02724 [Fig]Reduced adrenal ferredoxin + Cholesterol + O2 <=>4-Methylpentanal + 3beta-Hydroxypregn-5-en-20-one + Oxidized adrenal ferredoxin + H2O
R01454 [Fig]Cholesterol + NADPH + H+ + O2 <=>20alpha-Hydroxycholesterol + NADP+ + H2O
R03933 [Fig](22R)-20alpha,22-Dihydroxycholesterol + Ferredoxin + O2 <=>4-Methylpentanal + 3beta-Hydroxypregn-5-en-20-one + Ferredoxin

Cofactor(s)

Haem
BiSSCat v1.06.20 http://bisscat.org/
Developed by Masaaki Kotera, Department of Biochemistry, Trinity College Dublin.
Science Foundation of Ireland is gratefully acknowledged.