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Home Help FGROUP SUBSTRUCTURE compound enzyme Multiple

EC 1.14.15.4 steroid 11beta-monooxygenase

IUBMB ExplorEnz BRENDA KEGG ExPASy ERGO

Equation(s) (IUBMB)

a steroid + reduced adrenal ferredoxin + O2 = an 11beta-hydroxysteroid + oxidized adrenal ferredoxin + H2O

Reaction(s) (KEGG)

R04850 [Fig]17alpha,21-Dihydroxypregnenolone + NADPH + H+ + O2 <=>11beta,17alpha,21-Trihydroxypregnenolone + NADP+ + H2O
R03329 [Fig]17alpha-Hydroxy-4-pregnene-3,20-dione + NADPH + H+ + O2 <=>21-Deoxycortisol + NADP+ + H2O
R03851 [Fig]11-Deoxycorticosterone + Reduced ferredoxin + O2 <=>11beta,21-Dihydroxy-4-pregnene-3,20-dione + Oxidized ferredoxin + H2O
R02218 [Fig]4-Pregnene-3,20-dione + Reduced ferredoxin + O2 <=>11beta-Hydroxyprogesterone + Oxidized ferredoxin + H2O
R02725 [Fig]Reduced adrenal ferredoxin + 4-Androstene-3,17-dione + O2 <=>11beta-Hydroxyandrost-4-ene-3,17-dione + Oxidized adrenal ferredoxin + H2O
R02726 [Fig]Reduced adrenal ferredoxin + Steroid + O2 <=>11beta-Hydroxysteroid + Oxidized adrenal ferredoxin + H2O
R02843 [Fig]11-Deoxycortisol + Reduced ferredoxin + O2 <=>11beta,17alpha,21-Trihydroxy-4-pregnene-3,20-dione + Oxidized ferredoxin + H2O

Cofactor(s)

Haem
BiSSCat v1.06.20 http://bisscat.org/
Developed by Masaaki Kotera, Department of Biochemistry, Trinity College Dublin.
Science Foundation of Ireland is gratefully acknowledged.