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Home Help FGROUP SUBSTRUCTURE compound enzyme Multiple

EC 1.14.13.39 nitric-oxide synthase

IUBMB ExplorEnz BRENDA KEGG ExPASy ERGO

Equation(s) (IUBMB)

L-arginine + n NADPH + n H+ + m O2 = citrulline + nitric oxide + n NADP+

Reaction(s) (KEGG)

R00557 [Fig]L-Arginine + O2 + NADPH <=>INOmax + 2-Amino-5-ureidovaleric acid + NADP+
R00558 [Fig]L-Arginine + O2 + NADPH <=>N-(omega)-Hydroxyarginine + NADP+ + H2O
R00111 [Fig]NADPH + 2 N-(omega)-Hydroxyarginine + O2 + H+ <=>NADP+ + 2 INOmax + 2 2-Amino-5-ureidovaleric acid

Cofactor(s)

Ca2+

Inhibitor(s)

Ngamma-Nitro-L-arginine
Ngamma-Monomethyl-L-arginine
Ngamma-Nitro-L-arginine methyl ester
BiSSCat v1.06.20 http://bisscat.org/
Developed by Masaaki Kotera, Department of Biochemistry, Trinity College Dublin.
Science Foundation of Ireland is gratefully acknowledged.