Each ENZYME entry has an EC number and one or more names, which can be searched using the Text-search option. Other search options are described below. To begin the search, click on the hyperlink describing the type of search you want to perform.
| Method | Explanation | Detail |
| Text search | Use to look up enzymes by name or EC number | (Help) |
| Tree search | Use to view the Enzyme List arranged by class, subclass and sub-subclass, i.e. hierarchically | |
| Structure search | Use to search by reaction equation (either full or partial), as well as by substructure or by compound(s) found in enzyme reactions Examples: |