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EC 3.2.1.18 exo-alpha-sialidase

IUBMB ExplorEnz BRENDA KEGG ExPASy ERGO

Equation(s) (IUBMB)

Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates

Reaction(s) (KEGG)

R04650 [Fig]D-Galactosyl-1,3-beta-N-acetyl-D-galactosaminyl-(N- acetylneuraminyl)-D-galactosyl-D-glucosyl-N-acylsphingosine + 5-Acetamido-3,5-dideoxy-D-glycero-D-galacto-2-nonulosonic acid <=>GD1a + H2O
R04018 [Fig]Cerebroside + 5-Acetamido-3,5-dideoxy-D-glycero-D-galacto-2-nonulosonic acid <=>GM4 + H2O
R04634 [Fig]GM2 + H2O <=>GA2 + 5-Acetamido-3,5-dideoxy-D-glycero-D-galacto-2-nonulosonic acid
R03491 [Fig]D-Galactosyl-1,4-beta-D-glucosylceramide + 5-Acetamido-3,5-dideoxy-D-glycero-D-galacto-2-nonulosonic acid <=>(N-Acetylneuraminyl)-D-galactosyl-D-glucosylceramide + H2O
R05996 [Fig]G00116 + 5-Acetamido-3,5-dideoxy-D-glycero-D-galacto-2-nonulosonic acid <=>G00117 + H2O
R05998 [Fig]G00116 + H2O <=>G00115 + 5-Acetamido-3,5-dideoxy-D-glycero-D-galacto-2-nonulosonic acid
R05999 [Fig]G00092 + 5-Acetamido-3,5-dideoxy-D-glycero-D-galacto-2-nonulosonic acid <=>G00108 + H2O
R05115 [Fig]GT1b + 5-Acetamido-3,5-dideoxy-D-glycero-D-galacto-2-nonulosonic acid <=>GQ1 + H2O
R05117 [Fig]GT1b + H2O <=>GD1b + 5-Acetamido-3,5-dideoxy-D-glycero-D-galacto-2-nonulosonic acid
R06253 [Fig]G00110 + 5-Acetamido-3,5-dideoxy-D-glycero-D-galacto-2-nonulosonic acid <=>G00111 + H2O
R06147 [Fig]G11121 + 5-Acetamido-3,5-dideoxy-D-glycero-D-galacto-2-nonulosonic acid <=>G00317 + H2O
R06012 [Fig]G00109 + H2O <=>G00123 + 5-Acetamido-3,5-dideoxy-D-glycero-D-galacto-2-nonulosonic acid

Inhibitor(s)

2-Deoxy-2,3-dehydro-N-acetylneuraminic acid
BiSSCat v1.06.20 http://bisscat.org/
Developed by Masaaki Kotera, Department of Biochemistry, Trinity College Dublin.
Science Foundation of Ireland is gratefully acknowledged.