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EC 1.5.1.3 dihydrofolate reductase

IUBMB ExplorEnz BRENDA KEGG ExPASy ERGO

Equation(s) (IUBMB)

5,6,7,8-tetrahydrofolate + NADP+ = 7,8-dihydrofolate + NADPH + H+

Reaction(s) (KEGG)

R00940 [Fig]THF + NADP+ <=>Folate + NADPH
R02235 [Fig]7,8-Dihydrofolate + NAD+ <=>Folate + NADH + H+
R02236 [Fig]7,8-Dihydrofolate + NADP+ <=>Folate + NADPH + H+
R00936 [Fig]THF + NAD+ <=>7,8-Dihydrofolate + NADH + H+
R00937 [Fig]THF + NAD+ <=>Folate + NADH
R00939 [Fig]THF + NADP+ <=>7,8-Dihydrofolate + NADPH + H+

Inhibitor(s)

Methotrexate
Proloprim
BiSSCat v1.06.20 http://bisscat.org/
Developed by Masaaki Kotera, Department of Biochemistry, Trinity College Dublin.
Science Foundation of Ireland is gratefully acknowledged.