GREP C06002

Selected compound(s)

C06002 (S)-Methylmalonate semialdehyde

Each orphan metabolite is emphasized in bold. Click [Fig] on the left hand, and the image of the reaction is shown.
[Suggested reactions | Reported reactions]

Suggested reactions

[Fig] 1.1.1.- : (S)-3-Hydroxyisobutyrate + NAD+ = (S)-Methylmalonate semialdehyde + NADH + H+
[Fig] 1.1.1.- : (S)-Methylmalonate semialdehyde + NADPH + H+ = (S)-3-Hydroxyisobutyrate + NADP+
[Fig] 1.1.3.- : (S)-3-Hydroxyisobutyrate + O2 = (S)-Methylmalonate semialdehyde + H2O2
[Fig] 1.1.4.- : (S)-Methylmalonate semialdehyde + 1,4-Dithiothreitol = (S)-3-Hydroxyisobutyrate + Oxidized dithiothreitol
[Fig] 1.1.5.- : (S)-Methylmalonate semialdehyde + CoQH2 = (S)-3-Hydroxyisobutyrate + CoQ
[Fig] 1.1.99.- : (S)-3-Hydroxyisobutyrate + FAD = (S)-Methylmalonate semialdehyde + FADH2
[Fig] 1.1.99.- : (S)-3-Hydroxyisobutyrate + Coenzyme F420 = (S)-Methylmalonate semialdehyde + Reduced coenzyme F420
[Fig] 1.2.1.- : (S)-Methylmalonate semialdehyde + H2O + NAD+ = Methylmalonate + NADH + H+
[Fig] 1.2.1.- : (S)-Methylmalonate semialdehyde + H2O + NAD+ = Methylmalonate + NADH + H+
[Fig] 1.2.1.- : (S)-Methylmalonate semialdehyde + H2O + NADP+ = Methylmalonate + NADPH + H+
[Fig] 1.2.1.- : (S)-Methylmalonate semialdehyde + H2O + NADP+ = Methylmalonate + NADPH + H+
[Fig] 1.2.3.- : (S)-Methylmalonate semialdehyde + H2O + O2 = Methylmalonate + H2O2
[Fig] 1.2.3.- : (S)-Methylmalonate semialdehyde + H2O + O2 = Methylmalonate + H2O2
[Fig] 1.4.1.- : (S)-3-Amino-isobutanoate + H2O + NAD+ = (S)-Methylmalonate semialdehyde + NADH + Ammonia
[Fig] 1.4.1.- : (S)-3-Amino-isobutanoate + H2O + NAD+ = (S)-Methylmalonate semialdehyde + NADH + H+ + Ammonia
[Fig] 1.4.1.- : (S)-3-Amino-isobutanoate + H2O + NADP+ = (S)-Methylmalonate semialdehyde + NADPH + Ammonia
[Fig] 1.4.1.- : (S)-3-Amino-isobutanoate + H2O + NADP+ = (S)-Methylmalonate semialdehyde + NADPH + H+ + Ammonia
[Fig] 1.4.1.- : (S)-3-Amino-isobutanoate + NAD+ + H2O = (S)-Methylmalonate semialdehyde + Ammonia + NADH
[Fig] 1.4.1.- : (S)-3-Amino-isobutanoate + NAD+ + H2O = (S)-Methylmalonate semialdehyde + Ammonia + NADH + H+
[Fig] 1.4.1.- : (S)-3-Amino-isobutanoate + NADP+ + H2O = (S)-Methylmalonate semialdehyde + Ammonia + NADPH
[Fig] 1.4.1.- : (S)-3-Amino-isobutanoate + NADP+ + H2O = (S)-Methylmalonate semialdehyde + Ammonia + NADPH + H+
[Fig] 1.4.3.- : (S)-3-Amino-isobutanoate + H2O + O2 = (S)-Methylmalonate semialdehyde + Ammonia + H2O2
[Fig] 2.6.1.- : (S)-3-Amino-isobutanoate + Pyridoxal 5'-phosphate = (S)-Methylmalonate semialdehyde + Pyridoxamine 5'-phosphate
[Fig] 2.6.1.- : (S)-Methylmalonate semialdehyde + L-Glutamate = (S)-3-Amino-isobutanoate + 2-Ketoglutaric acid

Reported reactions

[Fig] EC 1.2.1.18 : (S)-Methylmalonate semialdehyde + CoA + NAD+ = (R)-2-Methyl-3-oxopropanoyl-CoA + NADH
[Fig] EC 1.2.3.1 : Methylmalonate + O2- = (S)-Methylmalonate semialdehyde + O2 + H2O
[Fig] EC 1.1.1.31 : (S)-3-Hydroxyisobutyrate + NAD+ = (S)-Methylmalonate semialdehyde + NADH + H+
[Fig] EC 1.1.1.35 : (S)-3-Hydroxyisobutyrate + NAD+ = (S)-Methylmalonate semialdehyde + NADH + H+
[Fig] EC 1.2.1.27 : (S)-Methylmalonate semialdehyde + CoA + NAD+ = Propanoyl-CoA + CO2 + NADH + H+
[Fig] EC 1.2.1.3 : (S)-Methylmalonate semialdehyde + NAD+ + H2O = Methylmalonate + NADH
[Fig] EC 2.6.1.18 : L-Alanine + (S)-Methylmalonate semialdehyde = 2-Oxopropanoate + (S)-3-Amino-isobutanoate
[Fig] EC 2.6.1.22 : (S)-3-Amino-isobutanoate + 2-Ketoglutaric acid = (S)-Methylmalonate semialdehyde + L-Glutamate

GREP v1.0.2 http://bisscat.org/GREP/
Developed by Masaaki Kotera (2008), Department of Biochemistry, Trinity College Dublin.
Science Foundation of Ireland is gratefully acknowledged.