GREP C05668

Selected compound(s)

C05668 3-Hydroxyisobutyryl coemzyme A

Each orphan metabolite is emphasized in bold. Click [Fig] on the left hand, and the image of the reaction is shown.
[Suggested reactions | Reported reactions]

Suggested reactions

[Fig] 1.1.1.- : 3-Hydroxyisobutyryl coemzyme A + H2O + 2 NAD+ = Malonyl-CoA + 2 NADH + 2 H+
[Fig] 1.1.1.- : 3-Hydroxyisobutyryl coemzyme A + H2O + 2 NAD+ = omega-Carboxyacyl-CoA + 2 NADH + 2 H+
[Fig] 1.1.1.- : 3-Hydroxyisobutyryl coemzyme A + H2O + 2 NADP+ = Malonyl-CoA + 2 NADPH + 2 H+
[Fig] 1.1.1.- : 3-Hydroxyisobutyryl coemzyme A + H2O + 2 NADP+ = omega-Carboxyacyl-CoA + 2 NADPH + 2 H+
[Fig] 1.1.1.- : 3-Hydroxyisobutyryl coemzyme A + H2O + NAD+ = Malonyl-CoA + NADH + H+
[Fig] 1.1.1.- : 3-Hydroxyisobutyryl coemzyme A + H2O + NAD+ = omega-Carboxyacyl-CoA + NADH + H+
[Fig] 1.1.1.- : 3-Hydroxyisobutyryl coemzyme A + H2O + NADP+ = Malonyl-CoA + NADPH + H+
[Fig] 1.1.1.- : 3-Hydroxyisobutyryl coemzyme A + H2O + NADP+ = omega-Carboxyacyl-CoA + NADPH + H+
[Fig] 1.1.1.- : 3-Hydroxyisobutyryl coemzyme A + NAD+ = 3-Oxopropionyl-CoA + NADH + H+
[Fig] 1.1.1.- : 3-Oxopropionyl-CoA + NADPH + H+ = 3-Hydroxyisobutyryl coemzyme A + NADP+
[Fig] 1.1.3.- : 3-Hydroxyisobutyryl coemzyme A + O2 = 3-Oxopropionyl-CoA + H2O2
[Fig] 1.1.4.- : 3-Hydroxyisobutyryl coemzyme A + H2O + Oxidized dithiothreitol = Malonyl-CoA + 1,4-Dithiothreitol
[Fig] 1.1.4.- : 3-Hydroxyisobutyryl coemzyme A + H2O + Oxidized dithiothreitol = omega-Carboxyacyl-CoA + 1,4-Dithiothreitol
[Fig] 1.1.4.- : 3-Oxopropionyl-CoA + 1,4-Dithiothreitol = 3-Hydroxyisobutyryl coemzyme A + Oxidized dithiothreitol
[Fig] 1.1.5.- : 3-Oxopropionyl-CoA + CoQH2 = 3-Hydroxyisobutyryl coemzyme A + CoQ
[Fig] 1.1.99.- : 3-Hydroxyisobutyryl coemzyme A + FAD = 3-Oxopropionyl-CoA + FADH2
[Fig] 1.1.99.- : 3-Hydroxyisobutyryl coemzyme A + Coenzyme F420 = 3-Oxopropionyl-CoA + Reduced coenzyme F420
[Fig] 1.14.11.- : Propanoyl-CoA + O2 + 2-Ketoglutaric acid = 3-Hydroxyisobutyryl coemzyme A + CO2 + Butanedionic acid
[Fig] 1.14.11.- : Long-chain acyl-CoA + O2 + 2-Ketoglutaric acid = 3-Hydroxyisobutyryl coemzyme A + CO2 + Butanedionic acid
[Fig] 1.14.13.- : 3-Hydroxyisobutyryl coemzyme A + H2O + NAD+ = Propanoyl-CoA + NADH + O2 + H+
[Fig] 1.14.13.- : 3-Hydroxyisobutyryl coemzyme A + H2O + NAD+ = Long-chain acyl-CoA + NADH + O2 + H+
[Fig] 1.14.13.- : 3-Hydroxyisobutyryl coemzyme A + H2O + NADP+ = Propanoyl-CoA + NADPH + O2 + H+
[Fig] 1.14.13.- : 3-Hydroxyisobutyryl coemzyme A + H2O + NADP+ = Long-chain acyl-CoA + NADPH + O2 + H+
[Fig] 1.14.16.- : 3-Hydroxyisobutyryl coemzyme A + 6,7-Dihydrobiopterin + H2O = Propanoyl-CoA + 2-Amino-6-(1,2-dihydroxypropyl)-5,6,7,8-tetrahydoro-4(1H)- pteridinone + O2
[Fig] 1.14.16.- : 3-Hydroxyisobutyryl coemzyme A + 6,7-Dihydrobiopterin + H2O = Long-chain acyl-CoA + 2-Amino-6-(1,2-dihydroxypropyl)-5,6,7,8-tetrahydoro-4(1H)- pteridinone + O2
[Fig] 1.14.17.- : Propanoyl-CoA + Vitamin C + O2 = 3-Hydroxyisobutyryl coemzyme A + Dehydroascorbate + H2O
[Fig] 1.14.17.- : Long-chain acyl-CoA + Vitamin C + O2 = 3-Hydroxyisobutyryl coemzyme A + Dehydroascorbate + H2O
[Fig] 2.1.1.- : 3-Hydroxyisobutyryl coemzyme A + S-Adenosyl-L-methionine = (S)-3-Hydroxybutanoyl-CoA + S-Adenosyl-L-homocysteine
[Fig] 2.1.1.- : 3-Hydroxyisobutyryl coemzyme A + S-Adenosyl-L-methionine = (S)-3-Hydroxybutanoyl-CoA + S-Adenosyl-L-homocysteine + H+
[Fig] 2.1.1.- : 3-Hydroxyisobutyryl coemzyme A + S-Adenosyl-L-methionine = (3R)-3-Hydroxybutanoyl-CoA + S-Adenosyl-L-homocysteine
[Fig] 2.1.1.- : 3-Hydroxyisobutyryl coemzyme A + S-Adenosyl-L-methionine = (3R)-3-Hydroxybutanoyl-CoA + S-Adenosyl-L-homocysteine + H+
[Fig] 2.1.1.- : 3-Hydroxyisobutyryl coemzyme A + S-Adenosyl-L-methionine = 3-Hydroxy-2-methylpropanoyl-CoA + S-Adenosyl-L-homocysteine
[Fig] 2.1.1.- : 3-Hydroxyisobutyryl coemzyme A + S-Adenosyl-L-methionine = 3-Hydroxy-2-methylpropanoyl-CoA + S-Adenosyl-L-homocysteine + H+
[Fig] 2.1.1.- : 3-Hydroxyisobutyryl coemzyme A + S-Adenosyl-L-methionine = 3-Hydroxybutanoyl-CoA + S-Adenosyl-L-homocysteine
[Fig] 2.1.1.- : 3-Hydroxyisobutyryl coemzyme A + S-Adenosyl-L-methionine = 3-Hydroxybutanoyl-CoA + S-Adenosyl-L-homocysteine + H+
[Fig] 2.1.2.- : (3S)-3-Carboxy-3-hydroxypropanoyl-CoA + THF = 3-Hydroxyisobutyryl coemzyme A + 10-Formyl-THF
[Fig] 3.1.2.- : 3-Hydroxyisobutyryl coemzyme A + H2O = CoA + 3-Hydroxypropanoate
[Fig] 3.3.2.- : (S)-3-Hydroxybutanoyl-CoA + H2O = 3-Hydroxyisobutyryl coemzyme A + Methanol
[Fig] 3.3.2.- : (3R)-3-Hydroxybutanoyl-CoA + H2O = 3-Hydroxyisobutyryl coemzyme A + Methanol
[Fig] 3.3.2.- : 3-Hydroxy-2-methylpropanoyl-CoA + H2O = 3-Hydroxyisobutyryl coemzyme A + Methanol
[Fig] 3.3.2.- : 3-Hydroxybutanoyl-CoA + H2O = 3-Hydroxyisobutyryl coemzyme A + Methanol
[Fig] 3.5.99.- : beta-Alanyl-CoA + H2O = 3-Hydroxyisobutyryl coemzyme A + Ammonia
[Fig] 3.7.1.- : (3S)-3-Carboxy-3-hydroxypropanoyl-CoA + H2O = 3-Hydroxyisobutyryl coemzyme A + Formate
[Fig] 4.1.1.- : 3-Hydroxyisobutyryl coemzyme A + CO2 = (3S)-3-Carboxy-3-hydroxypropanoyl-CoA
[Fig] 4.2.1.- : Acryloyl-CoA + H2O = 3-Hydroxyisobutyryl coemzyme A
[Fig] 6.2.1.- : CoA + 3-Hydroxypropanoate + ATP = 3-Hydroxyisobutyryl coemzyme A + ADP + Orthophosphate
[Fig] 6.2.1.- : CoA + 3-Hydroxypropanoate + ATP = 3-Hydroxyisobutyryl coemzyme A + Diphosphate + 5'-AMP
[Fig] 6.3.4.- : 3-Hydroxyisobutyryl coemzyme A + ATP + Ammonia = beta-Alanyl-CoA + ADP + Orthophosphate
[Fig] 6.3.4.- : 3-Hydroxyisobutyryl coemzyme A + ATP + Ammonia = beta-Alanyl-CoA + Diphosphate + 5'-AMP
[Fig] 6.4.1.- : (3S)-3-Carboxy-3-hydroxypropanoyl-CoA + ADP + Orthophosphate = 3-Hydroxyisobutyryl coemzyme A + Formate + ATP
[Fig] 6.4.1.- : 3-Hydroxyisobutyryl coemzyme A + ATP + Acid carbonate = (3S)-3-Carboxy-3-hydroxypropanoyl-CoA + ADP + Orthophosphate

Reported reactions

[Fig] EC 3.1.2.4 : 3-Hydroxyisobutyryl coemzyme A + Orthophosphate + ADP = 3-Hydroxypropanoate + CoA + ATP
[Fig] EC 6.2.1.- : 3-Hydroxyisobutyryl coemzyme A + Orthophosphate + ADP = 3-Hydroxypropanoate + CoA + ATP
[Fig] EC 4.2.1.17 : 3-Hydroxyisobutyryl coemzyme A = Acryloyl-CoA + H2O
[Fig] EC 3.1.2.4 : 3-Hydroxypropanoate + CoA = 3-Hydroxyisobutyryl coemzyme A + H2O

GREP v1.0.2 http://bisscat.org/GREP/
Developed by Masaaki Kotera (2008), Department of Biochemistry, Trinity College Dublin.
Science Foundation of Ireland is gratefully acknowledged.