GREP C05500

Selected compound(s)

C05500 20alpha-Hydroxycholesterol

Each orphan metabolite is emphasized in bold. Click [Fig] on the left hand, and the image of the reaction is shown.
[Suggested reactions | Reported reactions]

Suggested reactions

[Fig] 1.14.11.- : Cholesterol + O2 + 2-Ketoglutaric acid = 20alpha-Hydroxycholesterol + CO2 + Butanedionic acid
[Fig] 1.14.11.- : 20alpha-Hydroxycholesterol + O2 + 2-Ketoglutaric acid = 17alpha,20alpha-Dihydroxycholesterol + CO2 + Butanedionic acid
[Fig] 1.14.11.- : 20alpha-Hydroxycholesterol + O2 + 2-Ketoglutaric acid = (22R)-20alpha,22-Dihydroxycholesterol + CO2 + Butanedionic acid
[Fig] 1.14.13.- : 17alpha,20alpha-Dihydroxycholesterol + H2O + NAD+ = 20alpha-Hydroxycholesterol + NADH + O2 + H+
[Fig] 1.14.13.- : 17alpha,20alpha-Dihydroxycholesterol + H2O + NADP+ = 20alpha-Hydroxycholesterol + NADPH + O2 + H+
[Fig] 1.14.13.- : 20alpha-Hydroxycholesterol + H2O + NAD+ = Cholesterol + NADH + O2 + H+
[Fig] 1.14.13.- : 20alpha-Hydroxycholesterol + H2O + NADP+ = Cholesterol + NADPH + O2 + H+
[Fig] 1.14.16.- : 17alpha,20alpha-Dihydroxycholesterol + 6,7-Dihydrobiopterin + H2O = 20alpha-Hydroxycholesterol + 2-Amino-6-(1,2-dihydroxypropyl)-5,6,7,8-tetrahydoro-4(1H)- pteridinone + O2
[Fig] 1.14.16.- : 20alpha-Hydroxycholesterol + 6,7-Dihydrobiopterin + H2O = Cholesterol + 2-Amino-6-(1,2-dihydroxypropyl)-5,6,7,8-tetrahydoro-4(1H)- pteridinone + O2
[Fig] 1.14.17.- : Cholesterol + Vitamin C + O2 = 20alpha-Hydroxycholesterol + Dehydroascorbate + H2O
[Fig] 1.14.17.- : 20alpha-Hydroxycholesterol + Vitamin C + O2 = 17alpha,20alpha-Dihydroxycholesterol + Dehydroascorbate + H2O
[Fig] 1.17.1.- : Cholesterol + H2O + NAD+ = 20alpha-Hydroxycholesterol + NADH + H+
[Fig] 1.17.1.- : Cholesterol + H2O + NADP+ = 20alpha-Hydroxycholesterol + NADPH + H+
[Fig] 1.17.1.- : 20alpha-Hydroxycholesterol + H2O + NAD+ = 17alpha,20alpha-Dihydroxycholesterol + NADH + H+
[Fig] 1.17.1.- : 20alpha-Hydroxycholesterol + H2O + NADP+ = 17alpha,20alpha-Dihydroxycholesterol + NADPH + H+
[Fig] 1.17.3.- : Cholesterol + H2O + O2 = 20alpha-Hydroxycholesterol + H2O2
[Fig] 1.17.3.- : 20alpha-Hydroxycholesterol + H2O + O2 = 17alpha,20alpha-Dihydroxycholesterol + H2O2
[Fig] 1.17.4.- : Cholesterol + H2O + Oxidized thioredoxin = 20alpha-Hydroxycholesterol + Reduced thioredoxin
[Fig] 1.17.4.- : 20alpha-Hydroxycholesterol + H2O + Oxidized thioredoxin = 17alpha,20alpha-Dihydroxycholesterol + Reduced thioredoxin

Reported reactions

[Fig] EC 1.14.99.9 : 20alpha-Hydroxycholesterol + NADPH + H+ + O2 = 17alpha,20alpha-Dihydroxycholesterol + NADP+ + H2O
[Fig] EC 1.14.15.6 : 20alpha-Hydroxycholesterol + NADPH + H+ + O2 = (22R)-20alpha,22-Dihydroxycholesterol + NADP+ + H2O
[Fig] EC 1.14.15.6 : Cholesterol + NADPH + H+ + O2 = 20alpha-Hydroxycholesterol + NADP+ + H2O

GREP v1.0.2 http://bisscat.org/GREP/
Developed by Masaaki Kotera (2008), Department of Biochemistry, Trinity College Dublin.
Science Foundation of Ireland is gratefully acknowledged.