GREP C05485

Selected compound(s)

C05485 21-Hydroxypregnenolone

Each orphan metabolite is emphasized in bold. Click [Fig] on the left hand, and the image of the reaction is shown.
[Suggested reactions | Reported reactions]

Suggested reactions

[Fig] 1.1.1.- : 11-Deoxycorticosterone + NADPH + H+ = 21-Hydroxypregnenolone + NADP+
[Fig] 1.1.3.- : 21-Hydroxypregnenolone + O2 = 11-Deoxycorticosterone + H2O2
[Fig] 1.1.4.- : 11-Deoxycorticosterone + 1,4-Dithiothreitol = 21-Hydroxypregnenolone + Oxidized dithiothreitol
[Fig] 1.1.5.- : 11-Deoxycorticosterone + CoQH2 = 21-Hydroxypregnenolone + CoQ
[Fig] 1.1.99.- : 21-Hydroxypregnenolone + FAD = 11-Deoxycorticosterone + FADH2
[Fig] 1.1.99.- : 21-Hydroxypregnenolone + Coenzyme F420 = 11-Deoxycorticosterone + Reduced coenzyme F420
[Fig] 1.14.11.- : 3beta-Hydroxypregn-5-en-20-one + O2 + 2-Ketoglutaric acid = 21-Hydroxypregnenolone + CO2 + Butanedionic acid
[Fig] 1.14.13.- : 21-Hydroxypregnenolone + H2O + NAD+ = 3beta-Hydroxypregn-5-en-20-one + NADH + O2 + H+
[Fig] 1.14.13.- : 21-Hydroxypregnenolone + H2O + NADP+ = 3beta-Hydroxypregn-5-en-20-one + NADPH + O2 + H+
[Fig] 1.14.16.- : 21-Hydroxypregnenolone + 6,7-Dihydrobiopterin + H2O = 3beta-Hydroxypregn-5-en-20-one + 2-Amino-6-(1,2-dihydroxypropyl)-5,6,7,8-tetrahydoro-4(1H)- pteridinone + O2
[Fig] 1.14.17.- : 3beta-Hydroxypregn-5-en-20-one + Vitamin C + O2 = 21-Hydroxypregnenolone + Dehydroascorbate + H2O

Reported reactions

[Fig] EC 1.14.99.10 : 3beta-Hydroxypregn-5-en-20-one + Reduced acceptor + O2 = 21-Hydroxypregnenolone + Acceptor + H2O
[Fig] EC 1.1.1.145 : 21-Hydroxypregnenolone + NAD+ = 11-Deoxycorticosterone + NADH + H+
[Fig] EC 5.3.3.1 : 21-Hydroxypregnenolone + NAD+ = 11-Deoxycorticosterone + NADH + H+
[Fig] EC 1.1.1.145 : 21-Hydroxypregnenolone + NADP+ = 11-Deoxycorticosterone + NADPH + H+
[Fig] EC 5.3.3.1 : 21-Hydroxypregnenolone + NADP+ = 11-Deoxycorticosterone + NADPH + H+

GREP v1.0.2 http://bisscat.org/GREP/
Developed by Masaaki Kotera (2008), Department of Biochemistry, Trinity College Dublin.
Science Foundation of Ireland is gratefully acknowledged.