GREP C05202

Selected compound(s)

C05202 (S)-3'-Hydroxy-N-methylcoclaurine

Each orphan metabolite is emphasized in bold. Click [Fig] on the left hand, and the image of the reaction is shown.
[Suggested reactions | Reported reactions]

Suggested reactions

[Fig] 1.14.13.- : (S)-3'-Hydroxy-N-methylcoclaurine + H2O + NAD+ = (S)-1,2,3,4-Tetrahydro-1-[(4-hydroxyphenyl)methyl]-6-methoxy-2- methyl-7-isoquinolinol + NADH + O2 + H+
[Fig] 1.14.13.- : (S)-3'-Hydroxy-N-methylcoclaurine + H2O + NADP+ = (S)-1,2,3,4-Tetrahydro-1-[(4-hydroxyphenyl)methyl]-6-methoxy-2- methyl-7-isoquinolinol + NADPH + O2 + H+
[Fig] 2.1.1.- : (S)-3'-Hydroxy-N-methylcoclaurine + S-Adenosyl-L-methionine = (S)-Reticuline + S-Adenosyl-L-homocysteine
[Fig] 2.1.1.- : (S)-3'-Hydroxy-N-methylcoclaurine + S-Adenosyl-L-methionine = (S)-Reticuline + S-Adenosyl-L-homocysteine + H+
[Fig] 3.3.2.- : (S)-Reticuline + H2O = (S)-3'-Hydroxy-N-methylcoclaurine + Methanol

Reported reactions

[Fig] EC 2.1.1.116 : S-Adenosyl-L-methionine + (S)-3'-Hydroxy-N-methylcoclaurine = S-Adenosyl-L-homocysteine + (S)-Reticuline
[Fig] EC 1.14.13.71 : (S)-1,2,3,4-Tetrahydro-1-[(4-hydroxyphenyl)methyl]-6-methoxy-2- methyl-7-isoquinolinol + NADPH + H+ + O2 = (S)-3'-Hydroxy-N-methylcoclaurine + NADP+ + H2O
[Fig] EC 1.14.18.1 : (S)-1,2,3,4-Tetrahydro-1-[(4-hydroxyphenyl)methyl]-6-methoxy-2- methyl-7-isoquinolinol + O2 = (S)-3'-Hydroxy-N-methylcoclaurine + H2O

GREP v1.0.2 http://bisscat.org/GREP/
Developed by Masaaki Kotera (2008), Department of Biochemistry, Trinity College Dublin.
Science Foundation of Ireland is gratefully acknowledged.