GREP C04575

Selected compound(s)

C04575 (4R,5S)-4,5,6-Trihydroxy-2,3-dioxohexanoate

Each orphan metabolite is emphasized in bold. Click [Fig] on the left hand, and the image of the reaction is shown.
[Suggested reactions | Reported reactions]

Suggested reactions

[Fig] 1.1.1.- : 3-Dehydro-L-gulonate + NAD+ = (4R,5S)-4,5,6-Trihydroxy-2,3-dioxohexanoate + NADH + H+
[Fig] 1.1.1.- : (4R,5S)-4,5,6-Trihydroxy-2,3-dioxohexanoate + NADPH + H+ = 3-Dehydro-L-gulonate + NADP+
[Fig] 1.1.1.- : (4R,5S)-4,5,6-Trihydroxy-2,3-dioxohexanoate + NADPH + H+ = 2-Keto-D-gluconic acid + NADP+
[Fig] 1.1.1.- : 2-Keto-D-gluconic acid + NAD+ = (4R,5S)-4,5,6-Trihydroxy-2,3-dioxohexanoate + NADH + H+
[Fig] 1.1.3.- : 3-Dehydro-L-gulonate + O2 = (4R,5S)-4,5,6-Trihydroxy-2,3-dioxohexanoate + H2O2
[Fig] 1.1.3.- : 2-Keto-D-gluconic acid + O2 = (4R,5S)-4,5,6-Trihydroxy-2,3-dioxohexanoate + H2O2
[Fig] 1.1.4.- : (4R,5S)-4,5,6-Trihydroxy-2,3-dioxohexanoate + 1,4-Dithiothreitol = 3-Dehydro-L-gulonate + Oxidized dithiothreitol
[Fig] 1.1.4.- : (4R,5S)-4,5,6-Trihydroxy-2,3-dioxohexanoate + 1,4-Dithiothreitol = 2-Keto-D-gluconic acid + Oxidized dithiothreitol
[Fig] 1.1.5.- : 3-Dehydro-L-gulonate + Coenzyme F420 = (4R,5S)-4,5,6-Trihydroxy-2,3-dioxohexanoate + Reduced coenzyme F420
[Fig] 1.1.5.- : (4R,5S)-4,5,6-Trihydroxy-2,3-dioxohexanoate + Reduced thioredoxin = 3-Dehydro-L-gulonate + Oxidized thioredoxin
[Fig] 1.1.5.- : (4R,5S)-4,5,6-Trihydroxy-2,3-dioxohexanoate + Reduced thioredoxin = 2-Keto-D-gluconic acid + Oxidized thioredoxin
[Fig] 1.1.5.- : (4R,5S)-4,5,6-Trihydroxy-2,3-dioxohexanoate + CoQH2 = 3-Dehydro-L-gulonate + CoQ
[Fig] 1.1.5.- : (4R,5S)-4,5,6-Trihydroxy-2,3-dioxohexanoate + CoQH2 = 2-Keto-D-gluconic acid + CoQ
[Fig] 1.1.5.- : 2-Keto-D-gluconic acid + Coenzyme F420 = (4R,5S)-4,5,6-Trihydroxy-2,3-dioxohexanoate + Reduced coenzyme F420
[Fig] 1.1.99.- : 3-Dehydro-L-gulonate + FAD = (4R,5S)-4,5,6-Trihydroxy-2,3-dioxohexanoate + FADH2
[Fig] 1.1.99.- : 2-Keto-D-gluconic acid + FAD = (4R,5S)-4,5,6-Trihydroxy-2,3-dioxohexanoate + FADH2

Reported reactions

[Fig] EC 4.1.1.- : (4R,5S)-4,5,6-Trihydroxy-2,3-dioxohexanoate + H2O = L-Lyxonate + CO2
[Fig] EC 3.1.1.17 : L-Dehydroascorbate + H2O = (4R,5S)-4,5,6-Trihydroxy-2,3-dioxohexanoate
[Fig] EC 1.1.1.130 : 3-Dehydro-L-gulonate + NAD+ = (4R,5S)-4,5,6-Trihydroxy-2,3-dioxohexanoate + NADH
[Fig] EC 1.1.1.130 : 3-Dehydro-L-gulonate + NADP+ = (4R,5S)-4,5,6-Trihydroxy-2,3-dioxohexanoate + NADPH
[Fig] EC 4.1.1.- : (4R,5S)-4,5,6-Trihydroxy-2,3-dioxohexanoate + H2O = L-Xylonate + CO2

GREP v1.0.2 http://bisscat.org/GREP/
Developed by Masaaki Kotera (2008), Department of Biochemistry, Trinity College Dublin.
Science Foundation of Ireland is gratefully acknowledged.