GREP C04373

Selected compound(s)

C04373 3alpha-Hydroxy-5beta-androstan-17-one

Each orphan metabolite is emphasized in bold. Click [Fig] on the left hand, and the image of the reaction is shown.
[Suggested reactions | Reported reactions]

Suggested reactions

[Fig] 1.1.1.- : 5beta-Androstane-3,17-dione + NADPH + H+ = 3alpha-Hydroxy-5beta-androstan-17-one + NADP+
[Fig] 1.1.1.- : Androstan-3alpha,17beta-diol + NAD+ = 3alpha-Hydroxy-5beta-androstan-17-one + NADH + H+
[Fig] 1.1.1.- : 3alpha-Hydroxy-5beta-androstan-17-one + NAD+ = 5beta-Androstane-3,17-dione + NADH + H+
[Fig] 1.1.1.- : 3alpha-Hydroxy-5beta-androstan-17-one + NADPH + H+ = Androstan-3alpha,17beta-diol + NADP+
[Fig] 1.1.3.- : Androstan-3alpha,17beta-diol + O2 = 3alpha-Hydroxy-5beta-androstan-17-one + H2O2
[Fig] 1.1.3.- : 3alpha-Hydroxy-5beta-androstan-17-one + O2 = 5beta-Androstane-3,17-dione + H2O2
[Fig] 1.1.4.- : 5beta-Androstane-3,17-dione + 1,4-Dithiothreitol = 3alpha-Hydroxy-5beta-androstan-17-one + Oxidized dithiothreitol
[Fig] 1.1.4.- : 3alpha-Hydroxy-5beta-androstan-17-one + 1,4-Dithiothreitol = Androstan-3alpha,17beta-diol + Oxidized dithiothreitol
[Fig] 1.1.5.- : 5beta-Androstane-3,17-dione + Reduced thioredoxin = 3alpha-Hydroxy-5beta-androstan-17-one + Oxidized thioredoxin
[Fig] 1.1.5.- : 5beta-Androstane-3,17-dione + CoQH2 = 3alpha-Hydroxy-5beta-androstan-17-one + CoQ
[Fig] 1.1.5.- : Androstan-3alpha,17beta-diol + Coenzyme F420 = 3alpha-Hydroxy-5beta-androstan-17-one + Reduced coenzyme F420
[Fig] 1.1.5.- : 3alpha-Hydroxy-5beta-androstan-17-one + Reduced thioredoxin = Androstan-3alpha,17beta-diol + Oxidized thioredoxin
[Fig] 1.1.5.- : 3alpha-Hydroxy-5beta-androstan-17-one + CoQH2 = Androstan-3alpha,17beta-diol + CoQ
[Fig] 1.1.5.- : 3alpha-Hydroxy-5beta-androstan-17-one + Coenzyme F420 = 5beta-Androstane-3,17-dione + Reduced coenzyme F420
[Fig] 1.1.99.- : Androstan-3alpha,17beta-diol + FAD = 3alpha-Hydroxy-5beta-androstan-17-one + FADH2
[Fig] 1.1.99.- : 3alpha-Hydroxy-5beta-androstan-17-one + FAD = 5beta-Androstane-3,17-dione + FADH2
[Fig] 1.14.11.- : 3beta-Hydroxysteroid + O2 + 2-Ketoglutaric acid = 3alpha-Hydroxy-5beta-androstan-17-one + CO2 + Butanedionic acid
[Fig] 1.14.13.- : 3alpha-Hydroxy-5beta-androstan-17-one + H2O + NAD+ = 3beta-Hydroxysteroid + NADH + O2 + H+
[Fig] 1.14.13.- : 3alpha-Hydroxy-5beta-androstan-17-one + H2O + NADP+ = 3beta-Hydroxysteroid + NADPH + O2 + H+
[Fig] 1.14.16.- : 3alpha-Hydroxy-5beta-androstan-17-one + 6,7-Dihydrobiopterin + H2O = 3beta-Hydroxysteroid + 2-Amino-6-(1,2-dihydroxypropyl)-5,6,7,8-tetrahydoro-4(1H)- pteridinone + O2
[Fig] 1.14.17.- : 3beta-Hydroxysteroid + Vitamin C + O2 = 3alpha-Hydroxy-5beta-androstan-17-one + Dehydroascorbate + H2O
[Fig] 1.17.1.- : 3beta-Hydroxysteroid + H2O + NADP+ = 3alpha-Hydroxy-5beta-androstan-17-one + NADPH + H+
[Fig] 1.17.3.- : 3beta-Hydroxysteroid + H2O + O2 = 3alpha-Hydroxy-5beta-androstan-17-one + H2O2

Reported reactions

[Fig] EC 1.1.1.50 : 3alpha-Hydroxy-5beta-androstan-17-one + NAD+ = 5beta-Androstane-3,17-dione + NADH
[Fig] EC 1.1.1.152 : 3alpha-Hydroxy-5beta-androstan-17-one + NAD+ = 5beta-Androstane-3,17-dione + NADH
[Fig] EC 2.4.1.17 : 3alpha-Hydroxy-5beta-androstan-17-one + UDP-D-glucuronate = Etiocholan-3alpha-ol-17-one 3-glucuronide + UDP
[Fig] EC 1.1.1.50 : 3alpha-Hydroxy-5beta-androstan-17-one + NADP+ = 5beta-Androstane-3,17-dione + NADPH

GREP v1.0.2 http://bisscat.org/GREP/
Developed by Masaaki Kotera (2008), Department of Biochemistry, Trinity College Dublin.
Science Foundation of Ireland is gratefully acknowledged.