GREP C02557

Selected compound(s)

C02557 2-Methylmalonyl-CoA

Each orphan metabolite is emphasized in bold. Click [Fig] on the left hand, and the image of the reaction is shown.
[Suggested reactions | Reported reactions]

Suggested reactions

[Fig] 1.1.1.- : 3-Hydroxy-2-methylpropanoyl-CoA + H2O + 2 NAD+ = 2-Methylmalonyl-CoA + 2 NADH + 2 H+
[Fig] 1.1.1.- : 3-Hydroxy-2-methylpropanoyl-CoA + H2O + 2 NADP+ = 2-Methylmalonyl-CoA + 2 NADPH + 2 H+
[Fig] 1.1.1.- : 3-Hydroxy-2-methylpropanoyl-CoA + H2O + NAD+ = 2-Methylmalonyl-CoA + NADH + H+
[Fig] 1.1.1.- : 3-Hydroxy-2-methylpropanoyl-CoA + H2O + NADP+ = 2-Methylmalonyl-CoA + NADPH + H+
[Fig] 1.1.4.- : 3-Hydroxy-2-methylpropanoyl-CoA + H2O + Oxidized dithiothreitol = 2-Methylmalonyl-CoA + 1,4-Dithiothreitol
[Fig] 2.1.1.- : Malonyl-CoA + S-Adenosyl-L-methionine = 2-Methylmalonyl-CoA + S-Adenosyl-L-homocysteine
[Fig] 2.1.1.- : Malonyl-CoA + S-Adenosyl-L-methionine = 2-Methylmalonyl-CoA + S-Adenosyl-L-homocysteine + H+
[Fig] 2.1.1.- : omega-Carboxyacyl-CoA + S-Adenosyl-L-methionine = 2-Methylmalonyl-CoA + S-Adenosyl-L-homocysteine
[Fig] 2.1.1.- : omega-Carboxyacyl-CoA + S-Adenosyl-L-methionine = 2-Methylmalonyl-CoA + S-Adenosyl-L-homocysteine + H+
[Fig] 2.1.2.- : 2-Methylmalonyl-CoA + THF = Propanoyl-CoA + 10-Formyl-THF
[Fig] 2.1.2.- : 2-Methylmalonyl-CoA + THF = Long-chain acyl-CoA + 10-Formyl-THF
[Fig] 3.3.2.- : 2-Methylmalonyl-CoA + H2O = Malonyl-CoA + Methanol
[Fig] 3.3.2.- : 2-Methylmalonyl-CoA + H2O = omega-Carboxyacyl-CoA + Methanol
[Fig] 3.7.1.- : 2-Methylmalonyl-CoA + H2O = Propanoyl-CoA + Formate
[Fig] 3.7.1.- : 2-Methylmalonyl-CoA + H2O = Long-chain acyl-CoA + Formate
[Fig] 4.1.1.- : Propanoyl-CoA + CO2 = 2-Methylmalonyl-CoA
[Fig] 4.1.1.- : Long-chain acyl-CoA + CO2 = 2-Methylmalonyl-CoA
[Fig] 5.-.-.- : (S)-2-Methyl-3-oxopropanoyl-CoA = 2-Methylmalonyl-CoA
[Fig] 5.-.-.- : (R)-2-Methyl-3-oxopropanoyl-CoA = 2-Methylmalonyl-CoA
[Fig] 6.4.1.- : Propanoyl-CoA + ATP + Acid carbonate = 2-Methylmalonyl-CoA + ADP + Orthophosphate
[Fig] 6.4.1.- : 2-Methylmalonyl-CoA + ADP + Orthophosphate = Propanoyl-CoA + Formate + ATP
[Fig] 6.4.1.- : 2-Methylmalonyl-CoA + ADP + Orthophosphate = Long-chain acyl-CoA + Formate + ATP
[Fig] 6.4.1.- : Long-chain acyl-CoA + ATP + Acid carbonate = 2-Methylmalonyl-CoA + ADP + Orthophosphate

Reported reactions

[Fig] EC 4.1.1.9 : 2-Methylmalonyl-CoA = Propanoyl-CoA + CO2
[Fig] EC 2.3.1.94 : 6 2-Methylmalonyl-CoA + Propanoyl-CoA = 7 CoA + 6-Deoxyerythronolide B + 6 CO2
[Fig] EC 2.3.1.111 : Acyl-CoA + n 2-Methylmalonyl-CoA + 2n NADPH = Multi-methyl-branched acyl-CoA + n CoA + n CO2 + 2n NADP+ + n H2O

GREP v1.0.2 http://bisscat.org/GREP/
Developed by Masaaki Kotera (2008), Department of Biochemistry, Trinity College Dublin.
Science Foundation of Ireland is gratefully acknowledged.