GREP C01795

Selected compound(s)

C01795 Columbamine

Each orphan metabolite is emphasized in bold. Click [Fig] on the left hand, and the image of the reaction is shown.
[Suggested reactions | Reported reactions]

Suggested reactions

[Fig] 1.21.3.- : Columbamine + O2 = Berberine + H2O2
[Fig] 1.21.4.- : Berberine + 1,4-Dithiothreitol = Columbamine + Oxidized dithiothreitol
[Fig] 2.1.1.- : Columbamine + S-Adenosyl-L-methionine = 5,6-Dihydro-2,3,9,10-tetramethoxydibenzo[a,g]quinolizinium + S-Adenosyl-L-homocysteine
[Fig] 2.1.1.- : Columbamine + S-Adenosyl-L-methionine = 5,6-Dihydro-2,3,9,10-tetramethoxydibenzo[a,g]quinolizinium + S-Adenosyl-L-homocysteine + H+
[Fig] 3.3.2.- : 5,6-Dihydro-2,3,9,10-tetramethoxydibenzo[a,g]quinolizinium + H2O = Columbamine + Methanol

Reported reactions

[Fig] EC 2.1.1.118 : S-Adenosyl-L-methionine + Columbamine = S-Adenosyl-L-homocysteine + 5,6-Dihydro-2,3,9,10-tetramethoxydibenzo[a,g]quinolizinium
[Fig] EC 1.3.3.8 : (13aS)-5,8,13,13a-tetrahydro-3,9,10-trimethoxy-6H- Dibenzo[a,g]quinolizin-2-ol + 2 O2 = Columbamine + 2 H2O2
[Fig] EC 1.21.3.2 : 2 Columbamine + O2 = 2 Berberine + 2 H2O

GREP v1.0.2 http://bisscat.org/GREP/
Developed by Masaaki Kotera (2008), Department of Biochemistry, Trinity College Dublin.
Science Foundation of Ireland is gratefully acknowledged.