GREP C01188

Selected compound(s)

C01188 3-Hydroxy-2-methylpropanoate

Each orphan metabolite is emphasized in bold. Click [Fig] on the left hand, and the image of the reaction is shown.
[Suggested reactions | Reported reactions]

Suggested reactions

[Fig] 1.1.1.- : 2-Methyl-3-oxopropanoate + NADPH + H+ = 3-Hydroxy-2-methylpropanoate + NADP+
[Fig] 1.1.1.- : 3-Hydroxy-2-methylpropanoate + NAD+ = 2-Methyl-3-oxopropanoate + NADH + H+
[Fig] 1.1.3.- : 3-Hydroxy-2-methylpropanoate + O2 = 2-Methyl-3-oxopropanoate + H2O2
[Fig] 1.1.4.- : 2-Methyl-3-oxopropanoate + 1,4-Dithiothreitol = 3-Hydroxy-2-methylpropanoate + Oxidized dithiothreitol
[Fig] 1.1.5.- : 2-Methyl-3-oxopropanoate + CoQH2 = 3-Hydroxy-2-methylpropanoate + CoQ
[Fig] 1.1.99.- : 3-Hydroxy-2-methylpropanoate + FAD = 2-Methyl-3-oxopropanoate + FADH2
[Fig] 1.1.99.- : 3-Hydroxy-2-methylpropanoate + Coenzyme F420 = 2-Methyl-3-oxopropanoate + Reduced coenzyme F420
[Fig] 2.1.2.- : L-threo-3-Methylmalate + THF = 3-Hydroxy-2-methylpropanoate + 10-Formyl-THF
[Fig] 2.1.2.- : D-erythro-3-Methylmalate + THF = 3-Hydroxy-2-methylpropanoate + 10-Formyl-THF
[Fig] 3.1.2.- : 3-Hydroxy-2-methylpropanoyl-CoA + H2O = CoA + 3-Hydroxy-2-methylpropanoate
[Fig] 3.5.99.- : 3-Hydroxy-2-methylpropanoate + H2O = (R,S)-3-Amino-2-methylpropanoate + Ammonia
[Fig] 3.7.1.- : L-threo-3-Methylmalate + H2O = 3-Hydroxy-2-methylpropanoate + Formate
[Fig] 3.7.1.- : D-erythro-3-Methylmalate + H2O = 3-Hydroxy-2-methylpropanoate + Formate
[Fig] 4.1.1.- : 3-Hydroxy-2-methylpropanoate + CO2 = L-threo-3-Methylmalate
[Fig] 4.1.1.- : 3-Hydroxy-2-methylpropanoate + CO2 = D-erythro-3-Methylmalate
[Fig] 6.2.1.- : CoA + 3-Hydroxy-2-methylpropanoate + ATP = 3-Hydroxy-2-methylpropanoyl-CoA + ADP + Orthophosphate
[Fig] 6.2.1.- : CoA + 3-Hydroxy-2-methylpropanoate + ATP = 3-Hydroxy-2-methylpropanoyl-CoA + Diphosphate + 5'-AMP
[Fig] 6.3.4.- : (R,S)-3-Amino-2-methylpropanoate + ATP + Ammonia = 3-Hydroxy-2-methylpropanoate + ADP + Orthophosphate
[Fig] 6.3.4.- : (R,S)-3-Amino-2-methylpropanoate + ATP + Ammonia = 3-Hydroxy-2-methylpropanoate + Diphosphate + 5'-AMP
[Fig] 6.4.1.- : 3-Hydroxy-2-methylpropanoate + ATP + Acid carbonate = L-threo-3-Methylmalate + ADP + Orthophosphate
[Fig] 6.4.1.- : 3-Hydroxy-2-methylpropanoate + ATP + Acid carbonate = D-erythro-3-Methylmalate + ADP + Orthophosphate
[Fig] 6.4.1.- : L-threo-3-Methylmalate + ADP + Orthophosphate = 3-Hydroxy-2-methylpropanoate + Formate + ATP
[Fig] 6.4.1.- : D-erythro-3-Methylmalate + ADP + Orthophosphate = 3-Hydroxy-2-methylpropanoate + Formate + ATP

Reported reactions

[Fig] EC 3.1.2.4 : 3-Hydroxy-2-methylpropanoyl-CoA + H2O = 3-Hydroxy-2-methylpropanoate + CoA
[Fig] EC 1.1.1.31 : 3-Hydroxy-2-methylpropanoate + NAD+ = 2-Methyl-3-oxopropanoate + NADH

GREP v1.0.2 http://bisscat.org/GREP/
Developed by Masaaki Kotera (2008), Department of Biochemistry, Trinity College Dublin.
Science Foundation of Ireland is gratefully acknowledged.