GREP C01157

Selected compound(s)

C01157 trans-4-Hydroxy-L-proline

Each orphan metabolite is emphasized in bold. Click [Fig] on the left hand, and the image of the reaction is shown.
[Suggested reactions | Reported reactions]

Suggested reactions

[Fig] 1.1.1.- : trans-4-Hydroxy-L-proline + NAD+ = 4-Oxoproline + NADH + H+
[Fig] 1.1.1.- : 4-Oxoproline + NADPH + H+ = trans-4-Hydroxy-L-proline + NADP+
[Fig] 1.1.3.- : trans-4-Hydroxy-L-proline + O2 = 4-Oxoproline + H2O2
[Fig] 1.1.4.- : 4-Oxoproline + 1,4-Dithiothreitol = trans-4-Hydroxy-L-proline + Oxidized dithiothreitol
[Fig] 1.1.5.- : trans-4-Hydroxy-L-proline + Coenzyme F420 = 4-Oxoproline + Reduced coenzyme F420
[Fig] 1.1.5.- : 4-Oxoproline + Reduced thioredoxin = trans-4-Hydroxy-L-proline + Oxidized thioredoxin
[Fig] 1.1.5.- : 4-Oxoproline + CoQH2 = trans-4-Hydroxy-L-proline + CoQ
[Fig] 1.1.99.- : trans-4-Hydroxy-L-proline + FAD = 4-Oxoproline + FADH2
[Fig] 1.5.1.- : trans-4-Hydroxy-L-proline + NAD+ = 3-Hydroxy-L-1-pyrroline-5-carboxylate + NADH + H+
[Fig] 1.5.1.- : 3-Hydroxy-L-1-pyrroline-5-carboxylate + NADPH + H+ = trans-4-Hydroxy-L-proline + NADP+
[Fig] 1.5.3.- : trans-4-Hydroxy-L-proline + O2 = 3-Hydroxy-L-1-pyrroline-5-carboxylate + H2O2
[Fig] 1.5.4.- : 3-Hydroxy-L-1-pyrroline-5-carboxylate + 1,4-Dithiothreitol = trans-4-Hydroxy-L-proline + Oxidized dithiothreitol
[Fig] 1.5.5.- : 3-Hydroxy-L-1-pyrroline-5-carboxylate + CoQH2 = trans-4-Hydroxy-L-proline + CoQ
[Fig] 1.5.99.- : trans-4-Hydroxy-L-proline + Coenzyme F420 = 3-Hydroxy-L-1-pyrroline-5-carboxylate + Reduced coenzyme F420
[Fig] 1.14.11.- : L-Proline + O2 + 2-Ketoglutaric acid = trans-4-Hydroxy-L-proline + CO2 + Butanedionic acid
[Fig] 5.-.-.- : trans-4-Hydroxy-L-proline = cis-4-Hydroxy-D-proline

Reported reactions

[Fig] EC 1.1.1.104 : trans-4-Hydroxy-L-proline + NAD+ = 4-Oxoproline + NADH
[Fig] EC 1.5.1.2 : trans-4-Hydroxy-L-proline + NAD+ = 3-Hydroxy-L-1-pyrroline-5-carboxylate + NADH + H+
[Fig] EC 1.1.1.104 : trans-4-Hydroxy-L-proline + NADP+ = 4-Oxoproline + NADPH
[Fig] EC 1.5.1.2 : trans-4-Hydroxy-L-proline + NADP+ = 3-Hydroxy-L-1-pyrroline-5-carboxylate + NADPH + H+
[Fig] EC 1.5.1.12 : trans-4-Hydroxy-L-proline + FAD = 3-Hydroxy-L-1-pyrroline-5-carboxylate + FADH2
[Fig] EC 1.5.99.8 : trans-4-Hydroxy-L-proline + Acceptor = 3-Hydroxy-L-1-pyrroline-5-carboxylate + Reduced acceptor
[Fig] EC 5.1.1.8 : trans-4-Hydroxy-L-proline = cis-4-Hydroxy-D-proline
[Fig] EC 1.14.11.2 : L-Proline + 2-Ketoglutaric acid + O2 = trans-4-Hydroxy-L-proline + Butanedionic acid + CO2

GREP v1.0.2 http://bisscat.org/GREP/
Developed by Masaaki Kotera (2008), Department of Biochemistry, Trinity College Dublin.
Science Foundation of Ireland is gratefully acknowledged.