GREP C00695

Selected compound(s)

C00695 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholanate

Each orphan metabolite is emphasized in bold. Click [Fig] on the left hand, and the image of the reaction is shown.
[Suggested reactions | Reported reactions]

Suggested reactions

[Fig] 1.1.1.- : 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholanate + NAD+ = 3alpha,7alpha-Dihydroxy-12-oxo-5beta-cholanate + NADH + H+
[Fig] 1.1.1.- : 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholanate + NAD+ = 3alpha,12alpha-Dihydroxy-7-oxo-5beta-cholanate + NADH + H+
[Fig] 1.1.1.- : 3alpha,7alpha-Dihydroxy-12-oxo-5beta-cholanate + NADPH + H+ = 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholanate + NADP+
[Fig] 1.1.1.- : 3alpha,12alpha-Dihydroxy-7-oxo-5beta-cholanate + NADPH + H+ = 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholanate + NADP+
[Fig] 1.1.3.- : 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholanate + O2 = 3alpha,7alpha-Dihydroxy-12-oxo-5beta-cholanate + H2O2
[Fig] 1.1.3.- : 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholanate + O2 = 3alpha,12alpha-Dihydroxy-7-oxo-5beta-cholanate + H2O2
[Fig] 1.1.4.- : 3alpha,7alpha-Dihydroxy-12-oxo-5beta-cholanate + 1,4-Dithiothreitol = 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholanate + Oxidized dithiothreitol
[Fig] 1.1.4.- : 3alpha,12alpha-Dihydroxy-7-oxo-5beta-cholanate + 1,4-Dithiothreitol = 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholanate + Oxidized dithiothreitol
[Fig] 1.1.5.- : 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholanate + Coenzyme F420 = 3alpha,7alpha-Dihydroxy-12-oxo-5beta-cholanate + Reduced coenzyme F420
[Fig] 1.1.5.- : 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholanate + Coenzyme F420 = 3alpha,12alpha-Dihydroxy-7-oxo-5beta-cholanate + Reduced coenzyme F420
[Fig] 1.1.5.- : 3alpha,7alpha-Dihydroxy-12-oxo-5beta-cholanate + Reduced thioredoxin = 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholanate + Oxidized thioredoxin
[Fig] 1.1.5.- : 3alpha,7alpha-Dihydroxy-12-oxo-5beta-cholanate + CoQH2 = 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholanate + CoQ
[Fig] 1.1.5.- : 3alpha,12alpha-Dihydroxy-7-oxo-5beta-cholanate + Reduced thioredoxin = 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholanate + Oxidized thioredoxin
[Fig] 1.1.5.- : 3alpha,12alpha-Dihydroxy-7-oxo-5beta-cholanate + CoQH2 = 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholanate + CoQ
[Fig] 1.1.99.- : 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholanate + FAD = 3alpha,7alpha-Dihydroxy-12-oxo-5beta-cholanate + FADH2
[Fig] 1.1.99.- : 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholanate + FAD = 3alpha,12alpha-Dihydroxy-7-oxo-5beta-cholanate + FADH2
[Fig] 1.14.11.- : 3alpha,12alpha-Dihydroxy-5beta-cholanate + O2 + 2-Ketoglutaric acid = 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholanate + CO2 + Butanedionic acid
[Fig] 3.1.2.- : Choloyl-CoA + H2O = CoA + 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholanate
[Fig] 3.5.1.- : 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholan-24-oylglycine + H2O = 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholanate + Glycine
[Fig] 3.5.1.- : Cholyltaurine + H2O = 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholanate + 2-Aminoethanesulfonic acid
[Fig] 4.2.1.- : 3alpha,12alpha-Dihydroxy-5beta-chol-6-enoate + H2O = 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholanate
[Fig] 6.2.1.- : CoA + 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholanate + ATP = Choloyl-CoA + ADP + Orthophosphate
[Fig] 6.2.1.- : CoA + 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholanate + ATP = Choloyl-CoA + Diphosphate + 5'-AMP
[Fig] 6.3.1.- : 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholanate + Glycine + ATP = 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholan-24-oylglycine + ADP + Orthophosphate
[Fig] 6.3.1.- : 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholanate + Glycine + ATP = 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholan-24-oylglycine + Diphosphate + 5'-AMP
[Fig] 6.3.1.- : 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholanate + 2-Aminoethanesulfonic acid + ATP = Cholyltaurine + ADP + Orthophosphate
[Fig] 6.3.1.- : 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholanate + 2-Aminoethanesulfonic acid + ATP = Cholyltaurine + Diphosphate + 5'-AMP

Reported reactions

[Fig] EC 3.5.1.24 : 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholan-24-oylglycine + H2O = 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholanate + Glycine
[Fig] EC 1.1.1.159 : 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholanate + NAD+ = 3alpha,12alpha-Dihydroxy-7-oxo-5beta-cholanate + NADH
[Fig] EC 1.1.1.176 : 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholanate + NADP+ = 3alpha,7alpha-Dihydroxy-12-oxo-5beta-cholanate + NADPH
[Fig] EC 6.2.1.7 : ATP + 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholanate + CoA = 5'-AMP + Diphosphate + Choloyl-CoA
[Fig] EC 3.5.1.24 : Cholyltaurine + H2O = 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholanate + 2-Aminoethanesulfonic acid

GREP v1.0.2 http://bisscat.org/GREP/
Developed by Masaaki Kotera (2008), Department of Biochemistry, Trinity College Dublin.
Science Foundation of Ireland is gratefully acknowledged.