GREP C00535

Selected compound(s)

C00535 17beta-Hydroxy-4-androsten-3-one

Each orphan metabolite is emphasized in bold. Click [Fig] on the left hand, and the image of the reaction is shown.
[Suggested reactions | Reported reactions]

Suggested reactions

[Fig] 1.1.1.- : 4-Androstene-3,17-dione + NADPH + H+ = 17beta-Hydroxy-4-androsten-3-one + NADP+
[Fig] 1.1.1.- : 17beta-Hydroxy-4-androsten-3-one + NAD+ = 4-Androstene-3,17-dione + NADH + H+
[Fig] 1.1.3.- : 17beta-Hydroxy-4-androsten-3-one + O2 = 4-Androstene-3,17-dione + H2O2
[Fig] 1.1.4.- : 4-Androstene-3,17-dione + 1,4-Dithiothreitol = 17beta-Hydroxy-4-androsten-3-one + Oxidized dithiothreitol
[Fig] 1.1.5.- : 4-Androstene-3,17-dione + Reduced thioredoxin = 17beta-Hydroxy-4-androsten-3-one + Oxidized thioredoxin
[Fig] 1.1.5.- : 4-Androstene-3,17-dione + CoQH2 = 17beta-Hydroxy-4-androsten-3-one + CoQ
[Fig] 1.1.5.- : 17beta-Hydroxy-4-androsten-3-one + Coenzyme F420 = 4-Androstene-3,17-dione + Reduced coenzyme F420
[Fig] 1.1.99.- : 17beta-Hydroxy-4-androsten-3-one + FAD = 4-Androstene-3,17-dione + FADH2
[Fig] 1.3.1.- : 17beta-Hydroxy-4-androsten-3-one + NADPH + H+ = 17beta-Hydroxy-5alpha-androstan-3-one + NADP+
[Fig] 1.3.1.- : 17beta-Hydroxy-4-androsten-3-one + NADPH + H+ = 5beta-Dihydrotestosterone + NADP+
[Fig] 1.3.1.- : 17beta-Hydroxy-5alpha-androstan-3-one + NAD+ = 17beta-Hydroxy-4-androsten-3-one + NADH + H+
[Fig] 1.3.1.- : 5beta-Dihydrotestosterone + NAD+ = 17beta-Hydroxy-4-androsten-3-one + NADH + H+
[Fig] 1.3.3.- : 17beta-Hydroxy-5alpha-androstan-3-one + O2 = 17beta-Hydroxy-4-androsten-3-one + H2O2
[Fig] 1.3.3.- : 5beta-Dihydrotestosterone + O2 = 17beta-Hydroxy-4-androsten-3-one + H2O2
[Fig] 1.3.4.- : 17beta-Hydroxy-4-androsten-3-one + 1,4-Dithiothreitol = 17beta-Hydroxy-5alpha-androstan-3-one + Oxidized dithiothreitol
[Fig] 1.3.4.- : 17beta-Hydroxy-4-androsten-3-one + 1,4-Dithiothreitol = 5beta-Dihydrotestosterone + Oxidized dithiothreitol
[Fig] 1.3.5.- : 17beta-Hydroxy-4-androsten-3-one + CoQH2 = 17beta-Hydroxy-5alpha-androstan-3-one + CoQ
[Fig] 1.3.5.- : 17beta-Hydroxy-4-androsten-3-one + CoQH2 = 5beta-Dihydrotestosterone + CoQ
[Fig] 1.3.99.- : 17beta-Hydroxy-5alpha-androstan-3-one + FAD = 17beta-Hydroxy-4-androsten-3-one + FADH2
[Fig] 1.3.99.- : 17beta-Hydroxy-5alpha-androstan-3-one + Coenzyme F420 = 17beta-Hydroxy-4-androsten-3-one + Reduced coenzyme F420
[Fig] 1.3.99.- : 5beta-Dihydrotestosterone + FAD = 17beta-Hydroxy-4-androsten-3-one + FADH2
[Fig] 1.3.99.- : 5beta-Dihydrotestosterone + Coenzyme F420 = 17beta-Hydroxy-4-androsten-3-one + Reduced coenzyme F420
[Fig] 1.13.12.- : 11beta-Hydroxyandrost-4-ene-3,17-dione + H2O = 17beta-Hydroxy-4-androsten-3-one + O2
[Fig] 1.14.11.- : 17beta-Hydroxy-4-androsten-3-one + O2 + 2-Ketoglutaric acid = 7alpha-Hydroxytestosterone + CO2 + Butanedionic acid
[Fig] 1.14.11.- : 17beta-Hydroxy-4-androsten-3-one + O2 + 2-Ketoglutaric acid = 17beta,19-Dihydroxyandrost-4-en-3-one + CO2 + Butanedionic acid
[Fig] 1.14.13.- : 17beta-Hydroxy-4-androsten-3-one + H2O + NAD+ = 11beta-Hydroxyandrost-4-ene-3,17-dione + NADH + H+
[Fig] 1.14.13.- : 17beta-Hydroxy-4-androsten-3-one + H2O + NADP+ = 11beta-Hydroxyandrost-4-ene-3,17-dione + NADPH + H+
[Fig] 1.14.13.- : 17beta,19-Dihydroxyandrost-4-en-3-one + H2O + NAD+ = 17beta-Hydroxy-4-androsten-3-one + NADH + O2 + H+
[Fig] 1.14.13.- : 17beta,19-Dihydroxyandrost-4-en-3-one + H2O + NADP+ = 17beta-Hydroxy-4-androsten-3-one + NADPH + O2 + H+
[Fig] 1.14.16.- : 17beta,19-Dihydroxyandrost-4-en-3-one + 6,7-Dihydrobiopterin + H2O = 17beta-Hydroxy-4-androsten-3-one + 2-Amino-6-(1,2-dihydroxypropyl)-5,6,7,8-tetrahydoro-4(1H)- pteridinone + O2
[Fig] 1.14.17.- : 17beta-Hydroxy-4-androsten-3-one + Vitamin C + O2 = 17beta,19-Dihydroxyandrost-4-en-3-one + Dehydroascorbate + H2O
[Fig] 2.1.1.- : 17beta-Hydroxy-4-androsten-3-one + S-Adenosyl-L-methionine = Methyltestosterone + S-Adenosyl-L-homocysteine
[Fig] 2.1.1.- : 17beta-Hydroxy-4-androsten-3-one + S-Adenosyl-L-methionine = Methyltestosterone + S-Adenosyl-L-homocysteine + H+
[Fig] 3.3.2.- : Methyltestosterone + H2O = 17beta-Hydroxy-4-androsten-3-one + Methanol

Reported reactions

[Fig] EC 1.3.99.5 : 17beta-Hydroxy-5alpha-androstan-3-one + Acceptor = 17beta-Hydroxy-4-androsten-3-one + Reduced acceptor
[Fig] EC 1.3.99.6 : 5beta-Dihydrotestosterone + Acceptor = 17beta-Hydroxy-4-androsten-3-one + Reduced acceptor
[Fig] EC 1.1.1.145 : 17beta-Hydroxy-4-androsten-3-one + H+ + NADH = 3beta,17beta-Dihydroxy-5-androstene + NAD+
[Fig] EC 5.3.3.1 : 17beta-Hydroxy-4-androsten-3-one + H+ + NADH = 3beta,17beta-Dihydroxy-5-androstene + NAD+
[Fig] EC 1.1.1.145 : 17beta-Hydroxy-4-androsten-3-one + H+ + NADPH = 3beta,17beta-Dihydroxy-5-androstene + NADP+
[Fig] EC 5.3.3.1 : 17beta-Hydroxy-4-androsten-3-one + H+ + NADPH = 3beta,17beta-Dihydroxy-5-androstene + NADP+
[Fig] EC 1.14.13.- : 17beta-Hydroxy-4-androsten-3-one + H+ + O2 + NADPH = 17beta,19-Dihydroxyandrost-4-en-3-one + NADP+ + H2O
[Fig] EC 2.4.1.17 : 17beta-Hydroxy-4-androsten-3-one + UDP-D-glucuronate = Testosterone 17beta-(beta-D-glucuronide) + UDP
[Fig] EC 1.1.1.51 : 17beta-Hydroxy-4-androsten-3-one + NAD+ = 4-Androstene-3,17-dione + NADH + H+
[Fig] EC 1.1.1.63 : 17beta-Hydroxy-4-androsten-3-one + NAD+ = 4-Androstene-3,17-dione + NADH + H+
[Fig] EC 1.1.1.239 : 17beta-Hydroxy-4-androsten-3-one + NAD+ = 4-Androstene-3,17-dione + NADH + H+
[Fig] EC 1.1.1.51 : 17beta-Hydroxy-4-androsten-3-one + NADP+ = 4-Androstene-3,17-dione + NADPH + H+
[Fig] EC 1.1.1.64 : 17beta-Hydroxy-4-androsten-3-one + NADP+ = 4-Androstene-3,17-dione + NADPH + H+

GREP v1.0.2 http://bisscat.org/GREP/
Developed by Masaaki Kotera (2008), Department of Biochemistry, Trinity College Dublin.
Science Foundation of Ireland is gratefully acknowledged.