GREP C00468

Selected compound(s)

C00468 3-Hydroxy-1,3,5(10)-estratrien-17-one

Each orphan metabolite is emphasized in bold. Click [Fig] on the left hand, and the image of the reaction is shown.
[Suggested reactions | Reported reactions]

Suggested reactions

[Fig] 1.1.1.- : 3-Hydroxy-1,3,5(10)-estratrien-17-one + NADPH + H+ = Estrace + NADP+
[Fig] 1.1.1.- : 3-Hydroxy-1,3,5(10)-estratrien-17-one + NADPH + H+ = 17alpha-Estradiol + NADP+
[Fig] 1.1.1.- : Estrace + NAD+ = 3-Hydroxy-1,3,5(10)-estratrien-17-one + NADH + H+
[Fig] 1.1.1.- : 17alpha-Estradiol + NAD+ = 3-Hydroxy-1,3,5(10)-estratrien-17-one + NADH + H+
[Fig] 1.1.3.- : Estrace + O2 = 3-Hydroxy-1,3,5(10)-estratrien-17-one + H2O2
[Fig] 1.1.3.- : 17alpha-Estradiol + O2 = 3-Hydroxy-1,3,5(10)-estratrien-17-one + H2O2
[Fig] 1.1.4.- : 3-Hydroxy-1,3,5(10)-estratrien-17-one + 1,4-Dithiothreitol = Estrace + Oxidized dithiothreitol
[Fig] 1.1.4.- : 3-Hydroxy-1,3,5(10)-estratrien-17-one + 1,4-Dithiothreitol = 17alpha-Estradiol + Oxidized dithiothreitol
[Fig] 1.1.5.- : 3-Hydroxy-1,3,5(10)-estratrien-17-one + Reduced thioredoxin = Estrace + Oxidized thioredoxin
[Fig] 1.1.5.- : 3-Hydroxy-1,3,5(10)-estratrien-17-one + Reduced thioredoxin = 17alpha-Estradiol + Oxidized thioredoxin
[Fig] 1.1.5.- : 3-Hydroxy-1,3,5(10)-estratrien-17-one + CoQH2 = Estrace + CoQ
[Fig] 1.1.5.- : 3-Hydroxy-1,3,5(10)-estratrien-17-one + CoQH2 = 17alpha-Estradiol + CoQ
[Fig] 1.1.5.- : Estrace + Coenzyme F420 = 3-Hydroxy-1,3,5(10)-estratrien-17-one + Reduced coenzyme F420
[Fig] 1.1.5.- : 17alpha-Estradiol + Coenzyme F420 = 3-Hydroxy-1,3,5(10)-estratrien-17-one + Reduced coenzyme F420
[Fig] 1.1.99.- : Estrace + FAD = 3-Hydroxy-1,3,5(10)-estratrien-17-one + FADH2
[Fig] 1.1.99.- : 17alpha-Estradiol + FAD = 3-Hydroxy-1,3,5(10)-estratrien-17-one + FADH2
[Fig] 1.14.11.- : 3-Hydroxy-1,3,5(10)-estratrien-17-one + O2 + 2-Ketoglutaric acid = 16alpha-Hydroxyestrone + CO2 + Butanedionic acid
[Fig] 1.14.13.- : 2-Hydroxyestrone + H2O + NAD+ = 3-Hydroxy-1,3,5(10)-estratrien-17-one + NADH + O2 + H+
[Fig] 1.14.13.- : 2-Hydroxyestrone + H2O + NADP+ = 3-Hydroxy-1,3,5(10)-estratrien-17-one + NADPH + O2 + H+
[Fig] 2.8.2.- : 3-Hydroxy-1,3,5(10)-estratrien-17-one + 3'-Phospho-5'-adenylyl sulfate = Estrone 3-sulfate + 3'-Phosphoadenylate
[Fig] 3.1.6.- : Estrone 3-sulfate + H2O = Sulfate + 3-Hydroxy-1,3,5(10)-estratrien-17-one
[Fig] 3.1.6.- : Estrone 3-sulfate + H2O = 3-Hydroxy-1,3,5(10)-estratrien-17-one + Sulfate
[Fig] 4.2.1.- : 3-Hydroxy-1,3,5(10)-estratrien-17-one + H2O = 1,3,5(10)-Estratriene-3,16-alpha,17beta-triol

Reported reactions

[Fig] EC 3.1.6.1 : Estrone 3-sulfate + H2O = Sulfate + 3-Hydroxy-1,3,5(10)-estratrien-17-one
[Fig] EC 1.1.1.148 : 17alpha-Estradiol + NAD+ = 3-Hydroxy-1,3,5(10)-estratrien-17-one + NADH
[Fig] EC 1.1.1.148 : 17alpha-Estradiol + NADP+ = 3-Hydroxy-1,3,5(10)-estratrien-17-one + NADPH
[Fig] EC 2.8.2.4 : 3'-Phospho-5'-adenylyl sulfate + 3-Hydroxy-1,3,5(10)-estratrien-17-one = 3'-Phosphoadenylate + Estrone 3-sulfate
[Fig] EC 2.8.2.15 : 3'-Phospho-5'-adenylyl sulfate + 3-Hydroxy-1,3,5(10)-estratrien-17-one = 3'-Phosphoadenylate + Estrone 3-sulfate
[Fig] EC 1.14.99.- : 3-Hydroxy-1,3,5(10)-estratrien-17-one + Formate + NADP+ + H2O = 19-Oxoandrost-4-ene-3,17-dione + H+ + O2 + NADPH
[Fig] EC 1.1.1.51 : Estrace + NAD+ = 3-Hydroxy-1,3,5(10)-estratrien-17-one + NADH + H+
[Fig] EC 1.1.1.62 : Estrace + NAD+ = 3-Hydroxy-1,3,5(10)-estratrien-17-one + NADH + H+
[Fig] EC 1.1.1.51 : Estrace + NADP+ = 3-Hydroxy-1,3,5(10)-estratrien-17-one + NADPH + H+
[Fig] EC 1.1.1.62 : Estrace + NADP+ = 3-Hydroxy-1,3,5(10)-estratrien-17-one + NADPH + H+
[Fig] EC 1.14.13.- : 3-Hydroxy-1,3,5(10)-estratrien-17-one + H+ + O2 + NADH = 2-Hydroxyestrone + NAD+ + H2O
[Fig] EC 1.14.13.- : 3-Hydroxy-1,3,5(10)-estratrien-17-one + H+ + O2 + NADPH = 2-Hydroxyestrone + NADP+ + H2O
[Fig] EC 1.14.13.- : 3-Hydroxy-1,3,5(10)-estratrien-17-one + H+ + O2 + NADPH = 16alpha-Hydroxyestrone + NADP+ + H2O
[Fig] EC 2.4.1.17 : 3-Hydroxy-1,3,5(10)-estratrien-17-one + UDP-D-glucuronate = Estrone 3-glucuronide + UDP

GREP v1.0.2 http://bisscat.org/GREP/
Developed by Masaaki Kotera (2008), Department of Biochemistry, Trinity College Dublin.
Science Foundation of Ireland is gratefully acknowledged.