GREP C00410

Selected compound(s)

C00410 4-Pregnene-3,20-dione

Each orphan metabolite is emphasized in bold. Click [Fig] on the left hand, and the image of the reaction is shown.
[Suggested reactions | Reported reactions]

Suggested reactions

[Fig] 1.1.1.- : 4-Pregnene-3,20-dione + NADPH + H+ = 3beta-Hydroxypregn-5-en-20-one + NADP+
[Fig] 1.1.1.- : 4-Pregnene-3,20-dione + NADPH + H+ = 20alpha-Hydroxy-4-pregnen-3-one + NADP+
[Fig] 1.1.1.- : 20alpha-Hydroxy-4-pregnen-3-one + NAD+ = 4-Pregnene-3,20-dione + NADH + H+
[Fig] 1.1.3.- : 3beta-Hydroxypregn-5-en-20-one + O2 = 4-Pregnene-3,20-dione + H2O2
[Fig] 1.1.3.- : 20alpha-Hydroxy-4-pregnen-3-one + O2 = 4-Pregnene-3,20-dione + H2O2
[Fig] 1.1.4.- : 4-Pregnene-3,20-dione + 1,4-Dithiothreitol = 3beta-Hydroxypregn-5-en-20-one + Oxidized dithiothreitol
[Fig] 1.1.4.- : 4-Pregnene-3,20-dione + 1,4-Dithiothreitol = 20alpha-Hydroxy-4-pregnen-3-one + Oxidized dithiothreitol
[Fig] 1.1.5.- : 4-Pregnene-3,20-dione + Reduced thioredoxin = 20alpha-Hydroxy-4-pregnen-3-one + Oxidized thioredoxin
[Fig] 1.1.5.- : 4-Pregnene-3,20-dione + CoQH2 = 3beta-Hydroxypregn-5-en-20-one + CoQ
[Fig] 1.1.5.- : 4-Pregnene-3,20-dione + CoQH2 = 20alpha-Hydroxy-4-pregnen-3-one + CoQ
[Fig] 1.1.5.- : 20alpha-Hydroxy-4-pregnen-3-one + Coenzyme F420 = 4-Pregnene-3,20-dione + Reduced coenzyme F420
[Fig] 1.1.99.- : 3beta-Hydroxypregn-5-en-20-one + FAD = 4-Pregnene-3,20-dione + FADH2
[Fig] 1.1.99.- : 3beta-Hydroxypregn-5-en-20-one + Coenzyme F420 = 4-Pregnene-3,20-dione + Reduced coenzyme F420
[Fig] 1.1.99.- : 20alpha-Hydroxy-4-pregnen-3-one + FAD = 4-Pregnene-3,20-dione + FADH2
[Fig] 1.3.1.- : 4-Pregnene-3,20-dione + NADPH + H+ = 5alpha-Pregnane-3,20-dione + NADP+
[Fig] 1.3.1.- : 4-Pregnene-3,20-dione + NADPH + H+ = 5beta-Pregnane-3,20-dione + NADP+
[Fig] 1.3.1.- : 5alpha-Pregnane-3,20-dione + NAD+ = 4-Pregnene-3,20-dione + NADH + H+
[Fig] 1.3.1.- : 5beta-Pregnane-3,20-dione + NAD+ = 4-Pregnene-3,20-dione + NADH + H+
[Fig] 1.3.3.- : 5alpha-Pregnane-3,20-dione + O2 = 4-Pregnene-3,20-dione + H2O2
[Fig] 1.3.3.- : 5beta-Pregnane-3,20-dione + O2 = 4-Pregnene-3,20-dione + H2O2
[Fig] 1.3.4.- : 4-Pregnene-3,20-dione + 1,4-Dithiothreitol = 5alpha-Pregnane-3,20-dione + Oxidized dithiothreitol
[Fig] 1.3.4.- : 4-Pregnene-3,20-dione + 1,4-Dithiothreitol = 5beta-Pregnane-3,20-dione + Oxidized dithiothreitol
[Fig] 1.3.5.- : 4-Pregnene-3,20-dione + CoQH2 = 5alpha-Pregnane-3,20-dione + CoQ
[Fig] 1.3.5.- : 4-Pregnene-3,20-dione + CoQH2 = 5beta-Pregnane-3,20-dione + CoQ
[Fig] 1.3.99.- : 5alpha-Pregnane-3,20-dione + FAD = 4-Pregnene-3,20-dione + FADH2
[Fig] 1.3.99.- : 5alpha-Pregnane-3,20-dione + Coenzyme F420 = 4-Pregnene-3,20-dione + Reduced coenzyme F420
[Fig] 1.3.99.- : 5beta-Pregnane-3,20-dione + FAD = 4-Pregnene-3,20-dione + FADH2
[Fig] 1.3.99.- : 5beta-Pregnane-3,20-dione + Coenzyme F420 = 4-Pregnene-3,20-dione + Reduced coenzyme F420
[Fig] 1.13.12.- : 9,11alpha-Epoxypregn-4-ene-3,20-dione + H2O = 4-Pregnene-3,20-dione + O2
[Fig] 1.14.11.- : 4-Pregnene-3,20-dione + O2 + 2-Ketoglutaric acid = 17alpha-Hydroxy-4-pregnene-3,20-dione + CO2 + Butanedionic acid
[Fig] 1.14.11.- : 4-Pregnene-3,20-dione + O2 + 2-Ketoglutaric acid = 11-Deoxycorticosterone + CO2 + Butanedionic acid
[Fig] 1.14.11.- : 4-Pregnene-3,20-dione + O2 + 2-Ketoglutaric acid = 11alpha-Hydroxyprogesterone + CO2 + Butanedionic acid
[Fig] 1.14.11.- : 4-Pregnene-3,20-dione + O2 + 2-Ketoglutaric acid = 11beta-Hydroxyprogesterone + CO2 + Butanedionic acid
[Fig] 1.14.13.- : 4-Pregnene-3,20-dione + H2O + NAD+ = 9,11alpha-Epoxypregn-4-ene-3,20-dione + NADH + H+
[Fig] 1.14.13.- : 4-Pregnene-3,20-dione + H2O + NADP+ = 9,11alpha-Epoxypregn-4-ene-3,20-dione + NADPH + H+
[Fig] 1.14.13.- : 17alpha-Hydroxy-4-pregnene-3,20-dione + H2O + NAD+ = 4-Pregnene-3,20-dione + NADH + O2 + H+
[Fig] 1.14.13.- : 17alpha-Hydroxy-4-pregnene-3,20-dione + H2O + NADP+ = 4-Pregnene-3,20-dione + NADPH + O2 + H+
[Fig] 1.14.13.- : 11-Deoxycorticosterone + H2O + NAD+ = 4-Pregnene-3,20-dione + NADH + O2 + H+
[Fig] 1.14.13.- : 11-Deoxycorticosterone + H2O + NADP+ = 4-Pregnene-3,20-dione + NADPH + O2 + H+
[Fig] 1.14.16.- : 17alpha-Hydroxy-4-pregnene-3,20-dione + 6,7-Dihydrobiopterin + H2O = 4-Pregnene-3,20-dione + 2-Amino-6-(1,2-dihydroxypropyl)-5,6,7,8-tetrahydoro-4(1H)- pteridinone + O2
[Fig] 1.14.16.- : 11-Deoxycorticosterone + 6,7-Dihydrobiopterin + H2O = 4-Pregnene-3,20-dione + 2-Amino-6-(1,2-dihydroxypropyl)-5,6,7,8-tetrahydoro-4(1H)- pteridinone + O2
[Fig] 1.14.17.- : 4-Pregnene-3,20-dione + Vitamin C + O2 = 17alpha-Hydroxy-4-pregnene-3,20-dione + Dehydroascorbate + H2O
[Fig] 1.14.17.- : 4-Pregnene-3,20-dione + Vitamin C + O2 = 11-Deoxycorticosterone + Dehydroascorbate + H2O
[Fig] 1.17.1.- : 4-Pregnene-3,20-dione + H2O + NAD+ = 17alpha-Hydroxy-4-pregnene-3,20-dione + NADH + H+
[Fig] 1.17.1.- : 4-Pregnene-3,20-dione + H2O + NADP+ = 17alpha-Hydroxy-4-pregnene-3,20-dione + NADPH + H+
[Fig] 1.17.3.- : 4-Pregnene-3,20-dione + H2O + O2 = 17alpha-Hydroxy-4-pregnene-3,20-dione + H2O2
[Fig] 1.17.4.- : 4-Pregnene-3,20-dione + H2O + Oxidized thioredoxin = 17alpha-Hydroxy-4-pregnene-3,20-dione + Reduced thioredoxin

Reported reactions

[Fig] EC 1.14.13.54 : 4-Pregnene-3,20-dione + O2 + NADPH = Testosterone acetate + NADP+ + H2O
[Fig] EC 1.14.99.9 : 4-Pregnene-3,20-dione + Reduced acceptor + O2 = 17alpha-Hydroxy-4-pregnene-3,20-dione + Acceptor + H2O
[Fig] EC 1.14.99.4 : 4-Pregnene-3,20-dione + Reduced acceptor + O2 = Testosterone acetate + Acceptor + H2O
[Fig] EC 1.14.99.10 : 4-Pregnene-3,20-dione + Reduced acceptor + O2 = 11-Deoxycorticosterone + Acceptor + H2O
[Fig] EC 1.14.99.14 : 4-Pregnene-3,20-dione + Reduced acceptor + O2 = 11alpha-Hydroxyprogesterone + Acceptor + H2O
[Fig] EC 1.3.99.6 : 5beta-Pregnane-3,20-dione + Acceptor = 4-Pregnene-3,20-dione + Reduced acceptor
[Fig] EC 1.1.1.145 : 3beta-Hydroxypregn-5-en-20-one + NAD+ = 4-Pregnene-3,20-dione + NADH + H+
[Fig] EC 5.3.3.1 : 3beta-Hydroxypregn-5-en-20-one + NAD+ = 4-Pregnene-3,20-dione + NADH + H+
[Fig] EC 1.1.1.145 : 3beta-Hydroxypregn-5-en-20-one + NADP+ = 4-Pregnene-3,20-dione + NADPH + H+
[Fig] EC 5.3.3.1 : 3beta-Hydroxypregn-5-en-20-one + NADP+ = 4-Pregnene-3,20-dione + NADPH + H+
[Fig] EC 1.14.15.4 : 4-Pregnene-3,20-dione + Reduced ferredoxin + O2 = 11beta-Hydroxyprogesterone + Oxidized ferredoxin + H2O
[Fig] EC 1.3.99.6 : 4-Pregnene-3,20-dione + NADPH + H+ = 5beta-Pregnane-3,20-dione + NADP+
[Fig] EC 1.1.1.149 : 20alpha-Hydroxy-4-pregnen-3-one + NAD+ = 4-Pregnene-3,20-dione + NADH
[Fig] EC 1.3.1.30 : 5alpha-Pregnane-3,20-dione + NADP+ = 4-Pregnene-3,20-dione + NADPH
[Fig] EC 1.1.1.149 : 20alpha-Hydroxy-4-pregnen-3-one + NADP+ = 4-Pregnene-3,20-dione + NADPH

GREP v1.0.2 http://bisscat.org/GREP/
Developed by Masaaki Kotera (2008), Department of Biochemistry, Trinity College Dublin.
Science Foundation of Ireland is gratefully acknowledged.