GREP C00311

Selected compound(s)

C00311 1-Hydroxypropane-1,2,3-tricarboxylic acid

Each orphan metabolite is emphasized in bold. Click [Fig] on the left hand, and the image of the reaction is shown.
[Suggested reactions | Reported reactions]

Suggested reactions

[Fig] 1.1.1.- : 2-Ketoglutaric acid + NADPH + CO2 + H+ = 1-Hydroxypropane-1,2,3-tricarboxylic acid + NADP+
[Fig] 1.1.1.- : 2-Ketoglutaric acid + NADPH + CO2 = 1-Hydroxypropane-1,2,3-tricarboxylic acid + NADP+
[Fig] 1.1.1.- : 1-Hydroxypropane-1,2,3-tricarboxylic acid + NAD+ = 2-Ketoglutaric acid + NADH + CO2
[Fig] 1.1.1.- : 1-Hydroxypropane-1,2,3-tricarboxylic acid + NAD+ = 2-Ketoglutaric acid + NADH + CO2 + H+
[Fig] 1.1.1.- : 1-Hydroxypropane-1,2,3-tricarboxylic acid + NAD+ = Oxalosuccinate + NADH + H+
[Fig] 1.1.1.- : Oxalosuccinate + NADPH + H+ = 1-Hydroxypropane-1,2,3-tricarboxylic acid + NADP+
[Fig] 1.1.3.- : 1-Hydroxypropane-1,2,3-tricarboxylic acid + O2 = Oxalosuccinate + H2O2
[Fig] 1.1.4.- : Oxalosuccinate + 1,4-Dithiothreitol = 1-Hydroxypropane-1,2,3-tricarboxylic acid + Oxidized dithiothreitol
[Fig] 1.1.5.- : 1-Hydroxypropane-1,2,3-tricarboxylic acid + Coenzyme F420 = Oxalosuccinate + Reduced coenzyme F420
[Fig] 1.1.5.- : Oxalosuccinate + Reduced thioredoxin = 1-Hydroxypropane-1,2,3-tricarboxylic acid + Oxidized thioredoxin
[Fig] 1.1.5.- : Oxalosuccinate + CoQH2 = 1-Hydroxypropane-1,2,3-tricarboxylic acid + CoQ
[Fig] 1.1.99.- : 1-Hydroxypropane-1,2,3-tricarboxylic acid + FAD = Oxalosuccinate + FADH2
[Fig] 2.1.2.- : 1-Hydroxypropane-1,2,3-tricarboxylic acid + THF = 2-Hydroxyglutarate + 10-Formyl-THF
[Fig] 2.3.1.- : CoA + 2-Caffeoylisocitrate = Caffeoyl-CoA + 1-Hydroxypropane-1,2,3-tricarboxylic acid
[Fig] 3.7.1.- : 1-Hydroxypropane-1,2,3-tricarboxylic acid + H2O = 2-Hydroxyglutarate + Formate
[Fig] 4.1.1.- : 2-Hydroxyglutarate + CO2 = 1-Hydroxypropane-1,2,3-tricarboxylic acid
[Fig] 4.2.1.- : cis-Aconitate + H2O = 1-Hydroxypropane-1,2,3-tricarboxylic acid
[Fig] 6.4.1.- : 1-Hydroxypropane-1,2,3-tricarboxylic acid + ADP + Orthophosphate = 2-Hydroxyglutarate + Formate + ATP
[Fig] 6.4.1.- : 2-Hydroxyglutarate + ATP + Acid carbonate = 1-Hydroxypropane-1,2,3-tricarboxylic acid + ADP + Orthophosphate

Reported reactions

[Fig] EC 1.1.1.41 : 1-Hydroxypropane-1,2,3-tricarboxylic acid + NAD+ = 2-Ketoglutaric acid + CO2 + NADH + H+
[Fig] EC 1.1.1.42 : 1-Hydroxypropane-1,2,3-tricarboxylic acid + NADP+ = 2-Ketoglutaric acid + CO2 + NADPH + H+
[Fig] EC 1.1.1.42 : 1-Hydroxypropane-1,2,3-tricarboxylic acid + NADP+ = Oxalosuccinate + NADPH + H+
[Fig] EC 4.2.1.3 : Citrate = 1-Hydroxypropane-1,2,3-tricarboxylic acid
[Fig] EC 2.3.1.126 : Caffeoyl-CoA + 1-Hydroxypropane-1,2,3-tricarboxylic acid = CoA + 2-Caffeoylisocitrate
[Fig] EC 4.2.1.3 : 1-Hydroxypropane-1,2,3-tricarboxylic acid = cis-Aconitate + H2O
[Fig] EC 4.1.3.1 : 1-Hydroxypropane-1,2,3-tricarboxylic acid = Butanedionic acid + Glyoxalate

GREP v1.0.2 http://bisscat.org/GREP/
Developed by Masaaki Kotera (2008), Department of Biochemistry, Trinity College Dublin.
Science Foundation of Ireland is gratefully acknowledged.