GREP C00187

Selected compound(s)

C00187 Cholesterol

Each orphan metabolite is emphasized in bold. Click [Fig] on the left hand, and the image of the reaction is shown.
[Suggested reactions | Reported reactions]

Suggested reactions

[Fig] 1.1.1.- : 4-Cholesten-3-one + NADPH + H+ = Cholesterol + NADP+
[Fig] 1.1.3.- : Cholesterol + O2 = 4-Cholesten-3-one + H2O2
[Fig] 1.1.4.- : 4-Cholesten-3-one + 1,4-Dithiothreitol = Cholesterol + Oxidized dithiothreitol
[Fig] 1.1.5.- : 4-Cholesten-3-one + CoQH2 = Cholesterol + CoQ
[Fig] 1.1.99.- : Cholesterol + FAD = 4-Cholesten-3-one + FADH2
[Fig] 1.1.99.- : Cholesterol + Coenzyme F420 = 4-Cholesten-3-one + Reduced coenzyme F420
[Fig] 1.3.1.- : Cholesterol + NAD+ = 7-Dehydrocholesterol + NADH + H+
[Fig] 1.3.1.- : Cholesterol + NAD+ = 24-Dehydrocholesterol + NADH + H+
[Fig] 1.3.1.- : 7-Dehydrocholesterol + NADPH + H+ = Cholesterol + NADP+
[Fig] 1.3.1.- : 24-Dehydrocholesterol + NADPH + H+ = Cholesterol + NADP+
[Fig] 1.3.3.- : Cholesterol + O2 = 7-Dehydrocholesterol + H2O2
[Fig] 1.3.3.- : Cholesterol + O2 = 24-Dehydrocholesterol + H2O2
[Fig] 1.3.4.- : 7-Dehydrocholesterol + 1,4-Dithiothreitol = Cholesterol + Oxidized dithiothreitol
[Fig] 1.3.4.- : 24-Dehydrocholesterol + 1,4-Dithiothreitol = Cholesterol + Oxidized dithiothreitol
[Fig] 1.3.5.- : 7-Dehydrocholesterol + CoQH2 = Cholesterol + CoQ
[Fig] 1.3.5.- : 24-Dehydrocholesterol + CoQH2 = Cholesterol + CoQ
[Fig] 1.3.99.- : Cholesterol + FAD = 7-Dehydrocholesterol + FADH2
[Fig] 1.3.99.- : Cholesterol + FAD = 24-Dehydrocholesterol + FADH2
[Fig] 1.3.99.- : Cholesterol + Coenzyme F420 = 7-Dehydrocholesterol + Reduced coenzyme F420
[Fig] 1.3.99.- : Cholesterol + Coenzyme F420 = 24-Dehydrocholesterol + Reduced coenzyme F420
[Fig] 1.14.11.- : Cholesterol + O2 + 2-Ketoglutaric acid = 7alpha-Hydroxycholesterol + CO2 + Butanedionic acid
[Fig] 1.14.11.- : Cholesterol + O2 + 2-Ketoglutaric acid = 5beta,6beta-Epoxycholestan-3beta-ol + CO2 + Butanedionic acid
[Fig] 1.14.11.- : Cholesterol + O2 + 2-Ketoglutaric acid = 5alpha,6beta-Epoxycholestan-3beta-ol + CO2 + Butanedionic acid
[Fig] 1.14.11.- : Cholesterol + O2 + 2-Ketoglutaric acid = 20alpha-Hydroxycholesterol + CO2 + Butanedionic acid
[Fig] 1.14.11.- : Cholesterol + O2 + 2-Ketoglutaric acid = 22beta-Hydroxycholesterol + CO2 + Butanedionic acid
[Fig] 1.14.13.- : 5beta,6beta-Epoxycholestan-3beta-ol + H2O + NAD+ = Cholesterol + NADH + O2 + H+
[Fig] 1.14.13.- : 5beta,6beta-Epoxycholestan-3beta-ol + H2O + NADP+ = Cholesterol + NADPH + O2 + H+
[Fig] 1.14.13.- : 5alpha,6beta-Epoxycholestan-3beta-ol + H2O + NAD+ = Cholesterol + NADH + O2 + H+
[Fig] 1.14.13.- : 5alpha,6beta-Epoxycholestan-3beta-ol + H2O + NADP+ = Cholesterol + NADPH + O2 + H+
[Fig] 1.14.13.- : 20alpha-Hydroxycholesterol + H2O + NAD+ = Cholesterol + NADH + O2 + H+
[Fig] 1.14.13.- : 20alpha-Hydroxycholesterol + H2O + NADP+ = Cholesterol + NADPH + O2 + H+
[Fig] 1.14.16.- : 5beta,6beta-Epoxycholestan-3beta-ol + 6,7-Dihydrobiopterin + H2O = Cholesterol + 2-Amino-6-(1,2-dihydroxypropyl)-5,6,7,8-tetrahydoro-4(1H)- pteridinone + O2
[Fig] 1.14.16.- : 5alpha,6beta-Epoxycholestan-3beta-ol + 6,7-Dihydrobiopterin + H2O = Cholesterol + 2-Amino-6-(1,2-dihydroxypropyl)-5,6,7,8-tetrahydoro-4(1H)- pteridinone + O2
[Fig] 1.14.16.- : 20alpha-Hydroxycholesterol + 6,7-Dihydrobiopterin + H2O = Cholesterol + 2-Amino-6-(1,2-dihydroxypropyl)-5,6,7,8-tetrahydoro-4(1H)- pteridinone + O2
[Fig] 1.14.17.- : Cholesterol + Vitamin C + O2 = 5beta,6beta-Epoxycholestan-3beta-ol + Dehydroascorbate + H2O
[Fig] 1.14.17.- : Cholesterol + Vitamin C + O2 = 5alpha,6beta-Epoxycholestan-3beta-ol + Dehydroascorbate + H2O
[Fig] 1.14.17.- : Cholesterol + Vitamin C + O2 = 20alpha-Hydroxycholesterol + Dehydroascorbate + H2O
[Fig] 1.17.1.- : Cholesterol + H2O + NAD+ = 20alpha-Hydroxycholesterol + NADH + H+
[Fig] 1.17.1.- : Cholesterol + H2O + NADP+ = 20alpha-Hydroxycholesterol + NADPH + H+
[Fig] 1.17.3.- : Cholesterol + H2O + O2 = 20alpha-Hydroxycholesterol + H2O2
[Fig] 1.17.4.- : Cholesterol + H2O + Oxidized thioredoxin = 20alpha-Hydroxycholesterol + Reduced thioredoxin
[Fig] 2.3.1.- : Cholesterol ester + CoA = Cholesterol + Acyl-CoA
[Fig] 3.1.1.- : Cholesterol ester + H2O = Cholesterol + Carboxylate
[Fig] 3.1.1.- : Cholesterol ester + H2O = Cholesterol + Fatty acid
[Fig] 3.2.1.- : Cholesteryl-beta-D-glucoside + H2O = D-Glucose + Cholesterol
[Fig] 3.2.1.- : Cholesteryl-beta-D-glucoside + H2O = Hexose + Cholesterol

Reported reactions

[Fig] EC 3.2.1.104 : Cholesteryl-beta-D-glucoside + H2O = Cholesterol + D-Glucose
[Fig] EC 2.3.1.26 : Acyl-CoA + Cholesterol = CoA + Cholesterol ester
[Fig] EC 3.1.1.13 : Cholesterol ester + H2O = Cholesterol + Carboxylate
[Fig] EC 1.14.13.17 : Cholesterol + O2 + NADPH + H+ = 7alpha-Hydroxycholesterol + NADP+ + H2O
[Fig] EC 2.3.1.73 : 1,2-Diacyl-sn-glycerol + Cholesterol = 1-Monoacylglycerol + Cholesterol ester
[Fig] EC 1.14.15.6 : Cholesterol + NADPH + O2 = 22beta-Hydroxycholesterol + NADP+ + H2O
[Fig] EC 1.14.15.6 : Reduced adrenal ferredoxin + Cholesterol + O2 = 4-Methylpentanal + 3beta-Hydroxypregn-5-en-20-one + Oxidized adrenal ferredoxin + H2O
[Fig] EC 1.3.1.21 : Cholesterol + NAD+ = 7-Dehydrocholesterol + NADH + H+
[Fig] EC 1.14.13.- : Cholesterol + O2 + NADPH = 5alpha,6beta-Epoxycholestan-3beta-ol + NADP+ + H2O
[Fig] EC 1.14.13.- : Cholesterol + O2 + NADPH = 5beta,6beta-Epoxycholestan-3beta-ol + NADP+ + H2O
[Fig] EC 1.14.15.6 : Cholesterol + NADPH + H+ + O2 = 20alpha-Hydroxycholesterol + NADP+ + H2O
[Fig] EC 1.3.1.21 : Cholesterol + NADP+ = 7-Dehydrocholesterol + NADPH + H+
[Fig] EC 1.1.3.6 : Cholesterol + O2 = 4-Cholesten-3-one + H2O2

GREP v1.0.2 http://bisscat.org/GREP/
Developed by Masaaki Kotera (2008), Department of Biochemistry, Trinity College Dublin.
Science Foundation of Ireland is gratefully acknowledged.