GREP C00164

Selected compound(s)

C00164 Acetoacetate

Each orphan metabolite is emphasized in bold. Click [Fig] on the left hand, and the image of the reaction is shown.
[Suggested reactions | Reported reactions]

Suggested reactions

[Fig] 1.1.1.- : Acetoacetate + NADPH + H+ = (R)-3-Hydroxybutanoate + NADP+
[Fig] 1.1.1.- : Acetoacetate + NADPH + H+ = (S)-3-Hydroxybutanoate + NADP+
[Fig] 1.1.1.- : Acetoacetate + NADPH + H+ = (S)-3-Hydroxybutanoate + NADP+
[Fig] 1.1.1.- : (R)-3-Hydroxybutanoate + NAD+ = Acetoacetate + NADH + H+
[Fig] 1.1.1.- : (S)-3-Hydroxybutanoate + NAD+ = Acetoacetate + NADH + H+
[Fig] 1.1.1.- : (S)-3-Hydroxybutanoate + NAD+ = Acetoacetate + NADH + H+
[Fig] 1.1.3.- : (R)-3-Hydroxybutanoate + O2 = Acetoacetate + H2O2
[Fig] 1.1.3.- : (S)-3-Hydroxybutanoate + O2 = Acetoacetate + H2O2
[Fig] 1.1.3.- : (S)-3-Hydroxybutanoate + O2 = Acetoacetate + H2O2
[Fig] 1.1.4.- : Acetoacetate + 1,4-Dithiothreitol = (R)-3-Hydroxybutanoate + Oxidized dithiothreitol
[Fig] 1.1.4.- : Acetoacetate + 1,4-Dithiothreitol = (S)-3-Hydroxybutanoate + Oxidized dithiothreitol
[Fig] 1.1.4.- : Acetoacetate + 1,4-Dithiothreitol = (S)-3-Hydroxybutanoate + Oxidized dithiothreitol
[Fig] 1.1.5.- : Acetoacetate + Reduced thioredoxin = (R)-3-Hydroxybutanoate + Oxidized thioredoxin
[Fig] 1.1.5.- : Acetoacetate + Reduced thioredoxin = (S)-3-Hydroxybutanoate + Oxidized thioredoxin
[Fig] 1.1.5.- : Acetoacetate + Reduced thioredoxin = (S)-3-Hydroxybutanoate + Oxidized thioredoxin
[Fig] 1.1.5.- : Acetoacetate + CoQH2 = (R)-3-Hydroxybutanoate + CoQ
[Fig] 1.1.5.- : Acetoacetate + CoQH2 = (S)-3-Hydroxybutanoate + CoQ
[Fig] 1.1.5.- : Acetoacetate + CoQH2 = (S)-3-Hydroxybutanoate + CoQ
[Fig] 1.1.5.- : (R)-3-Hydroxybutanoate + Coenzyme F420 = Acetoacetate + Reduced coenzyme F420
[Fig] 1.1.5.- : (S)-3-Hydroxybutanoate + Coenzyme F420 = Acetoacetate + Reduced coenzyme F420
[Fig] 1.1.5.- : (S)-3-Hydroxybutanoate + Coenzyme F420 = Acetoacetate + Reduced coenzyme F420
[Fig] 1.1.99.- : (R)-3-Hydroxybutanoate + FAD = Acetoacetate + FADH2
[Fig] 1.1.99.- : (S)-3-Hydroxybutanoate + FAD = Acetoacetate + FADH2
[Fig] 1.1.99.- : (S)-3-Hydroxybutanoate + FAD = Acetoacetate + FADH2
[Fig] 1.14.11.- : Butanoate + O2 + 2-Ketoglutaric acid = Acetoacetate + CO2 + Butanedionic acid
[Fig] 1.14.13.- : Acetoacetate + H2O + NAD+ = Butanoate + NADH + O2 + H+
[Fig] 1.14.13.- : Acetoacetate + H2O + NADP+ = Butanoate + NADPH + O2 + H+
[Fig] 1.14.16.- : Acetoacetate + 6,7-Dihydrobiopterin + H2O = Butanoate + 2-Amino-6-(1,2-dihydroxypropyl)-5,6,7,8-tetrahydoro-4(1H)- pteridinone + O2
[Fig] 1.14.17.- : Butanoate + Vitamin C + O2 = Acetoacetate + Dehydroascorbate + H2O
[Fig] 1.17.1.- : Butanoate + H2O + NADP+ = Acetoacetate + NADPH + H+
[Fig] 1.17.3.- : Butanoate + H2O + O2 = Acetoacetate + H2O2
[Fig] 3.1.2.- : 3-Acetoacetyl-CoA + H2O = Acetoacetate + CoA
[Fig] 3.5.1.- : Acetoacetamide + H2O = Acetoacetate + Ammonia
[Fig] 3.7.1.- : 4-Fumarylacetoacetate + H2O = Acetoacetate + Fumarate
[Fig] 6.2.1.- : Acetoacetate + CoA + ATP = 3-Acetoacetyl-CoA + ADP + Orthophosphate
[Fig] 6.2.1.- : Acetoacetate + CoA + ATP = 3-Acetoacetyl-CoA + Diphosphate + 5'-AMP
[Fig] 6.3.4.- : Acetoacetate + ATP + Ammonia = Acetoacetamide + ADP + Orthophosphate
[Fig] 6.3.4.- : Acetoacetate + ATP + Ammonia = Acetoacetamide + Diphosphate + 5'-AMP
[Fig] 6.4.1.- : Acetoacetate + Fumarate + ATP = 4-Fumarylacetoacetate + ADP + Orthophosphate
[Fig] 6.4.1.- : Acetoacetate + Fumarate + ATP = 4-Fumarylacetoacetate + Diphosphate + 5'-AMP

Reported reactions

[Fig] EC 6.2.1.16 : ATP + Acetoacetate + CoA = 5'-AMP + Diphosphate + 3-Acetoacetyl-CoA
[Fig] EC 3.1.2.11 : 3-Acetoacetyl-CoA + H2O = Acetoacetate + CoA
[Fig] EC 2.8.3.8 : 3-Acetoacetyl-CoA + Acetate = Acetoacetate + Acetyl-CoA
[Fig] EC 6.4.1.6 : 2-Propanone + CO2 + ATP + 2 H2O = Acetoacetate + 5'-AMP + 2 Orthophosphate
[Fig] EC 1.8.1.5 : 2-Mercaptoethanesulfonate + Acetoacetate + NADP+ = 2-(2-Oxopropylthio)ethanesulfonate + CO2 + NADPH + H+
[Fig] EC 1.1.99.24 : (S)-3-Hydroxybutanoate + 2-Ketoglutaric acid = Acetoacetate + (R)-2-Hydroxyglutarate
[Fig] EC 4.1.3.4 : (S)-3-Hydroxy-3-methylglutaryl-CoA = Acetyl-CoA + Acetoacetate
[Fig] EC 1.1.1.30 : (R)-3-Hydroxybutanoate + NAD+ = Acetoacetate + NADH + H+
[Fig] EC 3.7.1.2 : Acetoacetate + Fumarate = 4-Fumarylacetoacetate + H2O
[Fig] EC 2.8.3.9 : Butanoyl-CoA + Acetoacetate = Butanoate + 3-Acetoacetyl-CoA
[Fig] EC 4.1.1.4 : Acetoacetate = 2-Propanone + CO2
[Fig] EC 4.2.1.27 : Acetoacetate = 3-Butynoate + H2O
[Fig] EC 2.8.3.5 : Succinyl-CoA + Acetoacetate = Butanedionic acid + 3-Acetoacetyl-CoA

GREP v1.0.2 http://bisscat.org/GREP/
Developed by Masaaki Kotera (2008), Department of Biochemistry, Trinity College Dublin.
Science Foundation of Ireland is gratefully acknowledged.