GREP C00109

Selected compound(s)

C00109 2-Ketobutyric acid

Each orphan metabolite is emphasized in bold. Click [Fig] on the left hand, and the image of the reaction is shown.
[Suggested reactions | Reported reactions]

Suggested reactions

[Fig] 1.1.1.- : 2-Ketobutyric acid + NADPH + CO2 + H+ = D-threo-3-Methylmalate + NADP+
[Fig] 1.1.1.- : 2-Ketobutyric acid + NADPH + CO2 + H+ = D-erythro-3-Methylmalate + NADP+
[Fig] 1.1.1.- : 2-Ketobutyric acid + NADPH + CO2 = D-threo-3-Methylmalate + NADP+
[Fig] 1.1.1.- : 2-Ketobutyric acid + NADPH + CO2 = D-erythro-3-Methylmalate + NADP+
[Fig] 1.1.1.- : 2-Ketobutyric acid + NADPH + H+ = 2-Hydroxybutanoic acid + NADP+
[Fig] 1.1.1.- : 2-Hydroxybutanoic acid + NAD+ = 2-Ketobutyric acid + NADH + H+
[Fig] 1.1.1.- : D-threo-3-Methylmalate + NAD+ = 2-Ketobutyric acid + NADH + CO2
[Fig] 1.1.1.- : D-threo-3-Methylmalate + NAD+ = 2-Ketobutyric acid + NADH + CO2 + H+
[Fig] 1.1.1.- : D-erythro-3-Methylmalate + NAD+ = 2-Ketobutyric acid + NADH + CO2
[Fig] 1.1.1.- : D-erythro-3-Methylmalate + NAD+ = 2-Ketobutyric acid + NADH + CO2 + H+
[Fig] 1.1.3.- : 2-Hydroxybutanoic acid + O2 = 2-Ketobutyric acid + H2O2
[Fig] 1.1.4.- : 2-Ketobutyric acid + 1,4-Dithiothreitol = 2-Hydroxybutanoic acid + Oxidized dithiothreitol
[Fig] 1.1.5.- : 2-Ketobutyric acid + Reduced thioredoxin = 2-Hydroxybutanoic acid + Oxidized thioredoxin
[Fig] 1.1.5.- : 2-Ketobutyric acid + CoQH2 = 2-Hydroxybutanoic acid + CoQ
[Fig] 1.1.5.- : 2-Hydroxybutanoic acid + Coenzyme F420 = 2-Ketobutyric acid + Reduced coenzyme F420
[Fig] 1.1.99.- : 2-Hydroxybutanoic acid + FAD = 2-Ketobutyric acid + FADH2
[Fig] 2.1.1.- : 2-Oxopropanoate + S-Adenosyl-L-methionine = 2-Ketobutyric acid + S-Adenosyl-L-homocysteine
[Fig] 2.1.1.- : 2-Oxopropanoate + S-Adenosyl-L-methionine = 2-Ketobutyric acid + S-Adenosyl-L-homocysteine + H+
[Fig] 2.1.2.- : 2-Ketoglutaric acid + THF = 2-Ketobutyric acid + 10-Formyl-THF
[Fig] 2.1.2.- : Methyloxaloacetate + THF = 2-Ketobutyric acid + 10-Formyl-THF
[Fig] 3.3.2.- : 2-Ketobutyric acid + H2O = 2-Oxopropanoate + Methanol
[Fig] 3.7.1.- : 2-Ketoglutaric acid + H2O = 2-Ketobutyric acid + Formate
[Fig] 3.7.1.- : Methyloxaloacetate + H2O = 2-Ketobutyric acid + Formate
[Fig] 4.1.1.- : 2-Ketobutyric acid + CO2 = 2-Ketoglutaric acid
[Fig] 4.1.1.- : 2-Ketobutyric acid + CO2 = Methyloxaloacetate
[Fig] 4.1.3.- : 2-Ketobutyric acid + Acetate = (R)-2-Ethylmalate
[Fig] 6.4.1.- : 2-Ketoglutaric acid + ADP + Orthophosphate = 2-Ketobutyric acid + Formate + ATP
[Fig] 6.4.1.- : 2-Ketobutyric acid + ATP + Acid carbonate = 2-Ketoglutaric acid + ADP + Orthophosphate
[Fig] 6.4.1.- : 2-Ketobutyric acid + ATP + Acid carbonate = Methyloxaloacetate + ADP + Orthophosphate
[Fig] 6.4.1.- : Methyloxaloacetate + ADP + Orthophosphate = 2-Ketobutyric acid + Formate + ATP

Reported reactions

[Fig] EC 2.2.1.6 : 2-Ketobutyric acid + 2-(alpha-Hydroxyethyl)thiamine diphosphate = (S)-2-Aceto-2-hydroxybutanoate + Thiamine diphosphate
[Fig] EC 1.2.7.1 : Oxidized ferredoxin + 2-Ketobutyric acid + CoA = Reduced ferredoxin + Propanoyl-CoA + CO2
[Fig] EC 1.2.7.2 : Oxidized ferredoxin + 2-Ketobutyric acid + CoA = Reduced ferredoxin + Propanoyl-CoA + CO2
[Fig] EC 4.4.1.2 : L-Homocysteine + H2O = H2S + Ammonia + 2-Ketobutyric acid
[Fig] EC 1.1.1.27 : 2-Hydroxybutanoic acid + NAD+ = 2-Ketobutyric acid + NADH + H+
[Fig] EC 4.4.1.1 : L-Cystathionine + H2O = L-Cysteine + Ammonia + 2-Ketobutyric acid
[Fig] EC 4.3.1.19 : L-Threonine = 2-Ketobutyric acid + Ammonia
[Fig] EC 3.5.99.7 : 1-Aminocyclopropane-1-carboxylate + H2O = 2-Ketobutyric acid + Ammonia
[Fig] EC 2.3.3.6 : (R)-2-Ethylmalate + CoA = Acetyl-CoA + H2O + 2-Ketobutyric acid
[Fig] EC 2.5.1.48 : O-Succinyl-L-homoserine + H2O = 2-Ketobutyric acid + Butanedionic acid + Ammonia
[Fig] EC 4.4.1.11 : Selenomethionine + H2O = Methaneselenol + Ammonia + 2-Ketobutyric acid
[Fig] EC 4.4.1.1 : Selenocystathionine + H2O = Selenocysteine + Ammonia + 2-Ketobutyric acid
[Fig] EC 2.3.1.54 : 2-Ketobutyric acid + CoA = Propanoyl-CoA + Formate
[Fig] EC 4.4.1.11 : L-Methionine + H2O = Methanethiol + Ammonia + 2-Ketobutyric acid

GREP v1.0.2 http://bisscat.org/GREP/
Developed by Masaaki Kotera (2008), Department of Biochemistry, Trinity College Dublin.
Science Foundation of Ireland is gratefully acknowledged.