GREP C00078

Selected compound(s)

C00078 L-Tryptophan

Each orphan metabolite is emphasized in bold. Click [Fig] on the left hand, and the image of the reaction is shown.
[Suggested reactions | Reported reactions]

Suggested reactions

[Fig] 1.3.1.- : L-Tryptophan + NAD+ = alpha,beta-Didehydrotryptophan + NADH + H+
[Fig] 1.3.1.- : alpha,beta-Didehydrotryptophan + NADPH + H+ = L-Tryptophan + NADP+
[Fig] 1.3.3.- : L-Tryptophan + O2 = alpha,beta-Didehydrotryptophan + H2O2
[Fig] 1.3.4.- : alpha,beta-Didehydrotryptophan + 1,4-Dithiothreitol = L-Tryptophan + Oxidized dithiothreitol
[Fig] 1.3.5.- : alpha,beta-Didehydrotryptophan + CoQH2 = L-Tryptophan + CoQ
[Fig] 1.3.99.- : L-Tryptophan + FAD = alpha,beta-Didehydrotryptophan + FADH2
[Fig] 1.3.99.- : L-Tryptophan + Coenzyme F420 = alpha,beta-Didehydrotryptophan + Reduced coenzyme F420
[Fig] 1.4.1.- : L-Tryptophan + H2O + NAD+ = (Indol-3-yl)pyruvate + NADH + Ammonia
[Fig] 1.4.1.- : L-Tryptophan + H2O + NAD+ = (Indol-3-yl)pyruvate + NADH + Ammonia + H+
[Fig] 1.4.1.- : L-Tryptophan + H2O + NAD+ = (Indol-3-yl)pyruvate + NADH + H+ + Ammonia
[Fig] 1.4.1.- : L-Tryptophan + H2O + NADP+ = (Indol-3-yl)pyruvate + NADPH + Ammonia
[Fig] 1.4.1.- : L-Tryptophan + H2O + NADP+ = (Indol-3-yl)pyruvate + NADPH + Ammonia + H+
[Fig] 1.4.1.- : L-Tryptophan + H2O + NADP+ = (Indol-3-yl)pyruvate + NADPH + H+ + Ammonia
[Fig] 1.4.1.- : L-Tryptophan + NAD+ + H2O = (Indol-3-yl)pyruvate + Ammonia + NADH
[Fig] 1.4.1.- : L-Tryptophan + NAD+ + H2O = (Indol-3-yl)pyruvate + Ammonia + NADH + H+
[Fig] 1.4.1.- : L-Tryptophan + NADP+ + H2O = (Indol-3-yl)pyruvate + Ammonia + NADPH
[Fig] 1.4.1.- : L-Tryptophan + NADP+ + H2O = (Indol-3-yl)pyruvate + Ammonia + NADPH + H+
[Fig] 1.4.3.- : L-Tryptophan + H2O + O2 = (Indol-3-yl)pyruvate + Ammonia + H2O2
[Fig] 1.14.13.- : 5-Hydroxy-L-tryptophan + H2O + NAD+ = L-Tryptophan + NADH + O2 + H+
[Fig] 1.14.13.- : 5-Hydroxy-L-tryptophan + H2O + NADP+ = L-Tryptophan + NADPH + O2 + H+
[Fig] 2.1.1.- : L-Tryptophan + S-Adenosyl-L-methionine = Abrine + S-Adenosyl-L-homocysteine
[Fig] 2.1.1.- : L-Tryptophan + S-Adenosyl-L-methionine = Abrine + S-Adenosyl-L-homocysteine + H+
[Fig] 2.1.2.- : L-Tryptophan + THF = 3-(2-Aminoethyl)indole + 10-Formyl-THF
[Fig] 2.5.1.- : L-Tryptophan + 2-Isopentenyl diphosphate = 4-(3-Methylbut-2-enyl)-L-tryptophan + Diphosphate
[Fig] 2.6.1.- : L-Tryptophan + Pyridoxal 5'-phosphate = (Indol-3-yl)pyruvate + Pyridoxamine 5'-phosphate
[Fig] 2.6.1.- : (Indol-3-yl)pyruvate + L-Glutamate = L-Tryptophan + 2-Ketoglutaric acid
[Fig] 3.1.1.- : Abrine + H2O = L-Tryptophan + Methanol
[Fig] 3.2.1.- : L-Tryptophanyl-tRNA(Trp) + H2O = L-Tryptophan + tRNA(Tyr)
[Fig] 3.2.1.- : L-Tryptophanyl-tRNA(Trp) + H2O = L-Tryptophan + tRNA(Cys)
[Fig] 3.2.1.- : L-Tryptophanyl-tRNA(Trp) + H2O = L-Tryptophan + tRNA(Gln)
[Fig] 3.2.1.- : L-Tryptophanyl-tRNA(Trp) + H2O = L-Tryptophan + tRNA(Glu)
[Fig] 3.2.1.- : L-Tryptophanyl-tRNA(Trp) + H2O = L-Tryptophan + tRNA(Trp)
[Fig] 3.2.1.- : L-Tryptophanyl-tRNA(Trp) + H2O = L-Tryptophan + tRNA(Val)
[Fig] 3.2.1.- : L-Tryptophanyl-tRNA(Trp) + H2O = tRNA(Arg) + L-Tryptophan
[Fig] 3.2.1.- : L-Tryptophanyl-tRNA(Trp) + H2O = tRNA(Ile) + L-Tryptophan
[Fig] 3.2.1.- : L-Tryptophanyl-tRNA(Trp) + H2O = tRNA(Leu) + L-Tryptophan
[Fig] 3.2.1.- : L-Tryptophanyl-tRNA(Trp) + H2O = tRNA(Met) + L-Tryptophan
[Fig] 3.5.1.- : L-Tryptophanamide + H2O = L-Tryptophan + Ammonia
[Fig] 3.7.1.- : L-Tryptophan + H2O = L-Serine + 2,3-Benzopyrrole
[Fig] 3.7.1.- : L-Tryptophan + H2O = 3-(2-Aminoethyl)indole + Formate
[Fig] 3.7.1.- : L-Tryptophan + H2O = 2-Amino-3-hydroxypropionic acid + 2,3-Benzopyrrole
[Fig] 4.1.1.- : 3-(2-Aminoethyl)indole + CO2 = L-Tryptophan
[Fig] 6.3.4.- : L-Tryptophan + ATP + Ammonia = L-Tryptophanamide + ADP + Orthophosphate
[Fig] 6.3.4.- : L-Tryptophan + ATP + Ammonia = L-Tryptophanamide + Diphosphate + 5'-AMP
[Fig] 6.4.1.- : L-Serine + 2,3-Benzopyrrole + ATP = L-Tryptophan + ADP + Orthophosphate
[Fig] 6.4.1.- : L-Serine + 2,3-Benzopyrrole + ATP = L-Tryptophan + Diphosphate + 5'-AMP
[Fig] 6.4.1.- : L-Tryptophan + ADP + Orthophosphate = 3-(2-Aminoethyl)indole + Formate + ATP
[Fig] 6.4.1.- : 3-(2-Aminoethyl)indole + ATP + Acid carbonate = L-Tryptophan + ADP + Orthophosphate
[Fig] 6.4.1.- : 2-Amino-3-hydroxypropionic acid + 2,3-Benzopyrrole + ATP = L-Tryptophan + ADP + Orthophosphate
[Fig] 6.4.1.- : 2-Amino-3-hydroxypropionic acid + 2,3-Benzopyrrole + ATP = L-Tryptophan + Diphosphate + 5'-AMP

Reported reactions

[Fig] EC 2.6.1.28 : L-Tryptophan + Phenylpyruvate = (Indol-3-yl)pyruvate + (S)-alpha-Amino-beta-phenylpropionic acid
[Fig] EC 1.3.3.10 : L-Tryptophan + O2 = alpha,beta-Didehydrotryptophan + H2O2
[Fig] EC 1.13.11.11 : L-Tryptophan + O2 = L-Formylkynurenine
[Fig] EC 1.13.99.3 : L-Tryptophan + O2 = 3-Indoleglycolaldehyde + Ammonia + CO2
[Fig] EC 3.5.1.57 : L-Tryptophanamide + H2O = L-Tryptophan + Ammonia
[Fig] EC 2.1.1.106 : S-Adenosyl-L-methionine + L-Tryptophan = S-Adenosyl-L-homocysteine + Abrine
[Fig] EC 2.6.1.27 : L-Tryptophan + 2-Ketoglutaric acid = (Indol-3-yl)pyruvate + L-Glutamate
[Fig] EC 4.1.1.28 : L-Tryptophan = 3-(2-Aminoethyl)indole + CO2
[Fig] EC 4.2.1.20 : L-Serine + (3-Indolyl)-glycerol phosphate = L-Tryptophan + Glyceraldehyde 3-phosphate + H2O
[Fig] EC 6.1.1.2 : ATP + L-Tryptophan + tRNA(Trp) = 5'-AMP + Diphosphate + L-Tryptophanyl-tRNA(Trp)
[Fig] EC 2.5.1.34 : 2-Isopentenyl diphosphate + L-Tryptophan = Diphosphate + 4-(3-Methylbut-2-enyl)-L-tryptophan
[Fig] EC 1.14.16.4 : 2-Amino-6-(1,2-dihydroxypropyl)-5,6,7,8-tetrahydoro-4(1H)- pteridinone + L-Tryptophan + O2 = 5-Hydroxy-L-tryptophan + 6,7-Dihydrobiopterin + H2O
[Fig] EC 4.1.99.1 : L-Tryptophan + H2O = 2,3-Benzopyrrole + 2-Oxopropanoate + Ammonia
[Fig] EC 4.2.1.20 : L-Serine + 2,3-Benzopyrrole = L-Tryptophan + H2O
[Fig] EC 1.4.1.19 : L-Tryptophan + NAD+ + H2O = (Indol-3-yl)pyruvate + Ammonia + NADH + H+
[Fig] EC 1.4.1.19 : L-Tryptophan + NADP+ + H2O = (Indol-3-yl)pyruvate + Ammonia + NADPH + H+
[Fig] EC 1.4.3.2 : L-Tryptophan + H2O + O2 = (Indol-3-yl)pyruvate + Ammonia + H2O2
[Fig] EC 1.13.11.11 : L-Tryptophan + O2 = Formylkynurenine
[Fig] EC 1.13.11.42 : L-Tryptophan + O2 = Formylkynurenine
[Fig] EC 1.13.12.3 : L-Tryptophan + O2 = Indole-3-acetamide + CO2 + H2O

GREP v1.0.2 http://bisscat.org/GREP/
Developed by Masaaki Kotera (2008), Department of Biochemistry, Trinity College Dublin.
Science Foundation of Ireland is gratefully acknowledged.