GREP C00068

Selected compound(s)

C00068 Thiamine diphosphate

Each orphan metabolite is emphasized in bold. Click [Fig] on the left hand, and the image of the reaction is shown.
[Suggested reactions | Reported reactions]

Suggested reactions

[Fig] 2.3.3.- : Thiamine diphosphate + 2-Hydroxy-3-oxoadipate = Succinate semialdehyde-thiamin diphosphate anion + Glyoxalate
[Fig] 2.5.1.- : L-Threonine + Thiamine diphosphate = Glycine + 2-(alpha-Hydroxyethyl)thiamine diphosphate
[Fig] 2.5.1.- : D-Threonine + Thiamine diphosphate = Glycine + 2-(alpha-Hydroxyethyl)thiamine diphosphate
[Fig] 2.5.1.- : (S)-3-Hydroxybutanoyl-CoA + Thiamine diphosphate = Acetyl-CoA + 2-(alpha-Hydroxyethyl)thiamine diphosphate
[Fig] 2.5.1.- : (3R)-3-Hydroxybutanoyl-CoA + Thiamine diphosphate = Acetyl-CoA + 2-(alpha-Hydroxyethyl)thiamine diphosphate
[Fig] 2.5.1.- : 4-Hydroxy-2-oxopentanoate + Thiamine diphosphate = 2-Oxopropanoate + 2-(alpha-Hydroxyethyl)thiamine diphosphate
[Fig] 2.5.1.- : 1-Deoxy-D-altro-heptulose 7-phosphate + Thiamine diphosphate = D-Ribose 5-phosphate + 2-(alpha-Hydroxyethyl)thiamine diphosphate
[Fig] 2.5.1.- : 1-Deoxy-D-altro-heptulose 7-phosphate + Thiamine diphosphate = L-Xylulose 5-phosphate + 2-(alpha-Hydroxyethyl)thiamine diphosphate
[Fig] 2.5.1.- : (2S,3S)-3-Hydroxy-2-methylbutanoyl-CoA + Thiamine diphosphate = Propanoyl-CoA + 2-(alpha-Hydroxyethyl)thiamine diphosphate
[Fig] 2.5.1.- : (2S,3S)-3-Hydroxy-2-methylbutanoyl-CoA + Thiamine diphosphate = Long-chain acyl-CoA + 2-(alpha-Hydroxyethyl)thiamine diphosphate
[Fig] 2.5.1.- : 3-Hydroxybutanoyl-CoA + Thiamine diphosphate = Acetyl-CoA + 2-(alpha-Hydroxyethyl)thiamine diphosphate
[Fig] 2.5.1.- : 5beta-Pregnane-3alpha,20alpha-diol + Thiamine diphosphate = 3alpha-Hydroxysteroid + 2-(alpha-Hydroxyethyl)thiamine diphosphate
[Fig] 2.5.1.- : L-Allothreonine + Thiamine diphosphate = Glycine + 2-(alpha-Hydroxyethyl)thiamine diphosphate
[Fig] 2.5.1.- : Triethanolamine + Thiamine diphosphate = Diethanolamine + 2-(alpha-Hydroxyethyl)thiamine diphosphate
[Fig] 2.5.1.- : Asclepin + Thiamine diphosphate = Uscharidin + 2-(alpha-Hydroxyethyl)thiamine diphosphate
[Fig] 2.5.1.- : D-Allothreonine + Thiamine diphosphate = Glycine + 2-(alpha-Hydroxyethyl)thiamine diphosphate
[Fig] 2.7.1.- : Thiamine diphosphate + ATP = Thiamin triphosphate + ADP
[Fig] 2.7.1.- : Thiamine diphosphate + Protein L-histidine = Thiamin triphosphate + Protein N(pai)-phosphohistidine
[Fig] 2.7.1.- : TMP + ATP = Thiamine diphosphate + ADP
[Fig] 2.7.1.- : TMP + Protein L-histidine = Thiamine diphosphate + Protein N(pai)-phosphohistidine
[Fig] 3.1.3.- : Thiamine diphosphate + H2O = Diphosphate + Aneurin
[Fig] 3.1.3.- : Thiamine diphosphate + H2O = TMP + Orthophosphate
[Fig] 3.1.3.- : Thiamin triphosphate + H2O = Thiamine diphosphate + Orthophosphate
[Fig] 3.1.7.- : Thiamine diphosphate + H2O = Orthophosphate + TMP
[Fig] 3.1.7.- : Thiamin triphosphate + H2O = Orthophosphate + Thiamine diphosphate

Reported reactions

[Fig] EC 2.2.1.6 : (S)-2-Acetolactate + Thiamine diphosphate = 2-(alpha-Hydroxyethyl)thiamine diphosphate + 2-Oxopropanoate
[Fig] EC 2.2.1.6 : 2-Ketobutyric acid + 2-(alpha-Hydroxyethyl)thiamine diphosphate = (S)-2-Aceto-2-hydroxybutanoate + Thiamine diphosphate
[Fig] EC 3.6.1.15 : Thiamine diphosphate + H2O = TMP + Orthophosphate
[Fig] EC 2.7.4.15 : ATP + Thiamine diphosphate = ADP + Thiamin triphosphate
[Fig] EC 2.7.6.2 : ATP + Thiamine diphosphate = ADP + Thiamin triphosphate
[Fig] EC 2.7.4.16 : ATP + TMP = ADP + Thiamine diphosphate
[Fig] EC 3.6.1.28 : Thiamin triphosphate + H2O = Thiamine diphosphate + Orthophosphate
[Fig] EC 2.7.6.2 : ATP + Aneurin = 5'-AMP + Thiamine diphosphate
[Fig] EC 2.2.1.3 : D-Xylulose 5-phosphate + Thiamine diphosphate = 2-(1,2-Dihydroxyethyl)-TPP + D-Glyceraldehyde 3-phosphate
[Fig] EC 2.2.1.3 : 2-(1,2-Dihydroxyethyl)-TPP + Formaldehyde = Thiamine diphosphate + Glycerone
[Fig] EC 2.2.1.1 : D-Sedoheptulose 7-phosphate + Thiamine diphosphate = 2-(1,2-Dihydroxyethyl)-TPP + D-Ribose 5-phosphate
[Fig] EC 2.2.1.1 : 2-(1,2-Dihydroxyethyl)-TPP + D-Glyceraldehyde 3-phosphate = Thiamine diphosphate + D-Xylulose 5-phosphate
[Fig] EC 1.2.4.1 : 2-(alpha-Hydroxyethyl)thiamine diphosphate + Lipoamide = 6-S-Acetyldihydrolipoamide + Thiamine diphosphate
[Fig] EC 2.2.1.6 : 2-Acetolactate + Thiamine diphosphate = 2-(alpha-Hydroxyethyl)thiamine diphosphate + 2-Oxopropanoate
[Fig] EC 4.1.1.1 : Acetaldehyde + Thiamine diphosphate = 2-(alpha-Hydroxyethyl)thiamine diphosphate
[Fig] EC 1.2.4.2 : 2-Ketoglutaric acid + Thiamine diphosphate = 3-Carboxy-1-hydroxypropyl-ThPP + CO2
[Fig] EC 4.1.1.71 : 2-Ketoglutaric acid + Thiamine diphosphate = Succinate semialdehyde-thiamin diphosphate anion + CO2
[Fig] EC 4.1.3.- : Succinate semialdehyde-thiamin diphosphate anion + Isochorismate = (1S,6R)-6-Hydroxy-2-succinylcyclohexa-2,4-diene-1-carboxylate + Thiamine diphosphate + 2-Oxopropanoate
[Fig] EC 1.2.4.2 : 3-Carboxy-1-hydroxypropyl-ThPP + Lipoamide = S-Succinyldihydrolipoamide + Thiamine diphosphate
[Fig] EC 1.2.4.1 : 2-(alpha-Hydroxyethyl)thiamine diphosphate + CO2 = Thiamine diphosphate + 2-Oxopropanoate
[Fig] EC 2.2.1.6 : 2-(alpha-Hydroxyethyl)thiamine diphosphate + CO2 = Thiamine diphosphate + 2-Oxopropanoate

GREP v1.0.2 http://bisscat.org/GREP/
Developed by Masaaki Kotera (2008), Department of Biochemistry, Trinity College Dublin.
Science Foundation of Ireland is gratefully acknowledged.