GREP C00065

Selected compound(s)

C00065 L-Serine

Each orphan metabolite is emphasized in bold. Click [Fig] on the left hand, and the image of the reaction is shown.
[Suggested reactions | Reported reactions]

Suggested reactions

[Fig] 1.1.1.- : L-Serine + NAD+ = 2-Aminomalonate semialdehyde + NADH + H+
[Fig] 1.1.1.- : 2-Aminomalonate semialdehyde + NADPH + H+ = L-Serine + NADP+
[Fig] 1.1.3.- : L-Serine + O2 = 2-Aminomalonate semialdehyde + H2O2
[Fig] 1.1.4.- : 2-Aminomalonate semialdehyde + 1,4-Dithiothreitol = L-Serine + Oxidized dithiothreitol
[Fig] 1.1.5.- : 2-Aminomalonate semialdehyde + CoQH2 = L-Serine + CoQ
[Fig] 1.1.99.- : L-Serine + FAD = 2-Aminomalonate semialdehyde + FADH2
[Fig] 1.1.99.- : L-Serine + Coenzyme F420 = 2-Aminomalonate semialdehyde + Reduced coenzyme F420
[Fig] 1.4.1.- : L-Serine + H2O + NAD+ = Hydroxypyruvate + NADH + Ammonia
[Fig] 1.4.1.- : L-Serine + H2O + NAD+ = Hydroxypyruvate + NADH + Ammonia + H+
[Fig] 1.4.1.- : L-Serine + H2O + NAD+ = Hydroxypyruvate + NADH + H+ + Ammonia
[Fig] 1.4.1.- : L-Serine + H2O + NADP+ = Hydroxypyruvate + NADPH + Ammonia
[Fig] 1.4.1.- : L-Serine + H2O + NADP+ = Hydroxypyruvate + NADPH + Ammonia + H+
[Fig] 1.4.1.- : L-Serine + H2O + NADP+ = Hydroxypyruvate + NADPH + H+ + Ammonia
[Fig] 1.4.1.- : L-Serine + NAD+ + H2O = Hydroxypyruvate + Ammonia + NADH
[Fig] 1.4.1.- : L-Serine + NAD+ + H2O = Hydroxypyruvate + Ammonia + NADH + H+
[Fig] 1.4.1.- : L-Serine + NADP+ + H2O = Hydroxypyruvate + Ammonia + NADPH
[Fig] 1.4.1.- : L-Serine + NADP+ + H2O = Hydroxypyruvate + Ammonia + NADPH + H+
[Fig] 1.4.3.- : L-Serine + H2O + O2 = Hydroxypyruvate + Ammonia + H2O2
[Fig] 1.14.11.- : L-Alanine + O2 + 2-Ketoglutaric acid = L-Serine + CO2 + Butanedionic acid
[Fig] 1.14.11.- : L-Alanine + O2 + 2-Ketoglutaric acid = L-Serine + CO2 + Butanedionic acid
[Fig] 1.14.13.- : L-Serine + H2O + NAD+ = L-Alanine + NADH + O2 + H+
[Fig] 1.14.13.- : L-Serine + H2O + NAD+ = L-Alanine + NADH + O2 + H+
[Fig] 1.14.13.- : L-Serine + H2O + NADP+ = L-Alanine + NADPH + O2 + H+
[Fig] 1.14.13.- : L-Serine + H2O + NADP+ = L-Alanine + NADPH + O2 + H+
[Fig] 1.14.16.- : L-Serine + 6,7-Dihydrobiopterin + H2O = L-Alanine + 2-Amino-6-(1,2-dihydroxypropyl)-5,6,7,8-tetrahydoro-4(1H)- pteridinone + O2
[Fig] 1.14.16.- : L-Serine + 6,7-Dihydrobiopterin + H2O = L-Alanine + 2-Amino-6-(1,2-dihydroxypropyl)-5,6,7,8-tetrahydoro-4(1H)- pteridinone + O2
[Fig] 1.14.17.- : L-Alanine + Vitamin C + O2 = L-Serine + Dehydroascorbate + H2O
[Fig] 1.14.17.- : L-Alanine + Vitamin C + O2 = L-Serine + Dehydroascorbate + H2O
[Fig] 2.3.1.- : O-Acetyl-L-serine + CoA = L-Serine + Acetyl-CoA
[Fig] 2.6.1.- : L-Serine + Pyridoxal 5'-phosphate = Hydroxypyruvate + Pyridoxamine 5'-phosphate
[Fig] 2.6.1.- : Hydroxypyruvate + L-Glutamate = L-Serine + 2-Ketoglutaric acid
[Fig] 2.7.1.- : Orthophosphate + 3-Phosphoserine = Diphosphate + L-Serine
[Fig] 2.7.1.- : L-Serine + ATP = 3-Phosphoserine + ADP
[Fig] 2.7.1.- : L-Serine + Protein L-histidine = 3-Phosphoserine + Protein N(pai)-phosphohistidine
[Fig] 3.1.1.- : O-Acetyl-L-serine + H2O = L-Serine + Acetate
[Fig] 3.1.3.- : 3-Phosphoserine + H2O = Orthophosphate + L-Serine
[Fig] 3.1.3.- : 3-Phosphoserine + H2O = L-Serine + Orthophosphate
[Fig] 3.1.3.- : L-Serine-phosphoethanolamine + H2O = L-Serine + Ethanolamine phosphate
[Fig] 3.2.1.- : L-Seryl-tRNA(Ser) + H2O = L-Serine + tRNA(Ser)
[Fig] 3.2.1.- : L-Seryl-tRNA(Ser) + H2O = 3'-Extranucleotides + L-Serine
[Fig] 3.2.1.- : D-Galactosyl-3-(N-acetyl-beta-D-galactosaminyl)-L-serine + H2O = L-Serine + D-Galactosyl-3-N-acetyl-beta-D-galactosamine
[Fig] 3.5.1.- : 2,3-Dihydroxy-N-benzoyl-L-serine + H2O = 2,3-Dihydroxybenzoate + L-Serine
[Fig] 3.5.99.- : 3-(Pyrazol-1-yl)-L-alanine + H2O = L-Serine + 1,2-Diazole
[Fig] 3.5.99.- : (S)-2-Amino-3-{[(E)-4-hydroxy-3-methylbut-2-enylamino]purin-9- yl}propanoic acid + H2O = L-Serine + (E)-2-Methyl-4-(1H-purin-6-ylamino)but-2-en-1-ol
[Fig] 3.5.99.- : (S)-2-Amino-3-(3-hydoxy-4-oxo-4H-pyridin-1-yl)propanoate + H2O = L-Serine + 3-Hydoxy-4-oxo-4H-pyrid-4-one
[Fig] 3.5.99.- : 2,3-Diaminopropanoate + H2O = L-Serine + Ammonia
[Fig] 3.7.1.- : L-Tryptophan + H2O = L-Serine + 2,3-Benzopyrrole
[Fig] 3.8.1.- : 3-Fluoro-D-alanine + H2O = L-Serine + F- + H+
[Fig] 3.13.1.- : L-Cysteine + H2O = L-Serine + H2S
[Fig] 4.1.2.- : Glycine + Formaldehyde = L-Serine
[Fig] 4.1.2.- : Glycine + Formaldehyde = L-Serine
[Fig] 4.3.1.- : 3-Oxopropanoate + Ammonia = L-Serine
[Fig] 5.-.-.- : L-Serine = D-Serine
[Fig] 6.3.1.- : 2,3-Dihydroxybenzoate + L-Serine + ATP = 2,3-Dihydroxy-N-benzoyl-L-serine + ADP + Orthophosphate
[Fig] 6.3.1.- : 2,3-Dihydroxybenzoate + L-Serine + ATP = 2,3-Dihydroxy-N-benzoyl-L-serine + Diphosphate + 5'-AMP
[Fig] 6.3.4.- : L-Serine + ATP + Ammonia = 2,3-Diaminopropanoate + ADP + Orthophosphate
[Fig] 6.3.4.- : L-Serine + ATP + Ammonia = 2,3-Diaminopropanoate + Diphosphate + 5'-AMP
[Fig] 6.3.4.- : L-Serine + (E)-2-Methyl-4-(1H-purin-6-ylamino)but-2-en-1-ol + ATP = (S)-2-Amino-3-{[(E)-4-hydroxy-3-methylbut-2-enylamino]purin-9- yl}propanoic acid + ADP + Orthophosphate
[Fig] 6.3.4.- : L-Serine + (E)-2-Methyl-4-(1H-purin-6-ylamino)but-2-en-1-ol + ATP = (S)-2-Amino-3-{[(E)-4-hydroxy-3-methylbut-2-enylamino]purin-9- yl}propanoic acid + Diphosphate + 5'-AMP
[Fig] 6.3.4.- : L-Serine + 1,2-Diazole + ATP = 3-(Pyrazol-1-yl)-L-alanine + ADP + Orthophosphate
[Fig] 6.3.4.- : L-Serine + 1,2-Diazole + ATP = 3-(Pyrazol-1-yl)-L-alanine + Diphosphate + 5'-AMP
[Fig] 6.3.4.- : L-Serine + 3-Hydoxy-4-oxo-4H-pyrid-4-one + ATP = (S)-2-Amino-3-(3-hydoxy-4-oxo-4H-pyridin-1-yl)propanoate + ADP + Orthophosphate
[Fig] 6.3.4.- : L-Serine + 3-Hydoxy-4-oxo-4H-pyrid-4-one + ATP = (S)-2-Amino-3-(3-hydoxy-4-oxo-4H-pyridin-1-yl)propanoate + Diphosphate + 5'-AMP
[Fig] 6.4.1.- : L-Serine + 2,3-Benzopyrrole + ATP = L-Tryptophan + ADP + Orthophosphate
[Fig] 6.4.1.- : L-Serine + 2,3-Benzopyrrole + ATP = L-Tryptophan + Diphosphate + 5'-AMP

Reported reactions

[Fig] EC 2.1.2.1 : 5,10-Methylene-THF + Glycine + H2O = THF + L-Serine
[Fig] EC 3.2.1.110 : D-Galactosyl-3-(N-acetyl-beta-D-galactosaminyl)-L-serine + H2O = D-Galactosyl-3-N-acetyl-beta-D-galactosamine + L-Serine
[Fig] EC 4.2.1.22 : L-Serine + Selenohomocysteine = Selenocystathionine + H2O
[Fig] EC 2.1.2.- : 5,6,7,8-Tetrahydromethanopterin + L-Serine = 5,10-Methylenetetrahydromethanopterin + Glycine + H2O
[Fig] EC 2.3.1.50 : Hexadecanoyl-CoA + L-Serine = 3-Dehydro-D-sphinganine + CoA + CO2
[Fig] EC 4.2.1.22 : L-Serine + L-Homocysteine = Cystathionine + H2O
[Fig] EC 2.8.1.4 : L-Cysteine + 'Activated' tRNA = L-Serine + tRNA containing a thionucleotide
[Fig] EC 6.3.2.14 : ATP + 2,3-Dihydroxybenzoate + L-Serine = 5'-AMP + 2,3-Dihydroxy-N-benzoyl-L-serine + Diphosphate
[Fig] EC 2.7.8.8 : CDP-1,2-diacylglycerol + L-Serine = CMP + 1,2-Diacyl-sn-glycerol 3-phospho-L-serine
[Fig] EC 2.7.8.4 : CDPethanolamine + L-Serine = CMP + L-Serine-phosphoethanolamine
[Fig] EC 4.3.1.17 : L-Serine = 2-Aminoacrylate + H2O
[Fig] EC 4.2.1.20 : L-Serine + (3-Indolyl)-glycerol phosphate = L-Tryptophan + Glyceraldehyde 3-phosphate + H2O
[Fig] EC 4.3.1.17 : L-Serine = 2-Oxopropanoate + Ammonia
[Fig] EC 4.3.1.19 : L-Serine = 2-Oxopropanoate + Ammonia
[Fig] EC 3.5.1.61 : (S)-2-Amino-3-(3-hydoxy-4-oxo-4H-pyridin-1-yl)propanoate + H2O = 3-Hydoxy-4-oxo-4H-pyrid-4-one + L-Serine
[Fig] EC 3.2.1.110 : T antigen + H2O = G10607 + L-Serine
[Fig] EC 1.1.1.276 : L-Serine + NADP+ = 2-Aminomalonate semialdehyde + NADPH + H+
[Fig] EC 4.2.1.22 : L-Serine + L-Homocysteine = L-Cystathionine + H2O
[Fig] EC 6.1.1.11 : ATP + L-Serine + tRNA(Ser) = 5'-AMP + Diphosphate + L-Seryl-tRNA(Ser)
[Fig] EC 6.3.2.14 : ATP + 2,3-Dihydroxybenzoate + L-Serine = ADP + 2,3-Dihydroxy-N-benzoyl-L-serine + Orthophosphate
[Fig] EC 4.2.1.50 : L-Serine + 1,2-Diazole = 3-(Pyrazol-1-yl)-L-alanine + H2O
[Fig] EC 2.7.7.- : L-Serine + ATP = (L-Seryl)adenylate + Diphosphate
[Fig] EC 1.4.1.7 : L-Serine + NAD+ + H2O = Hydroxypyruvate + Ammonia + NADH
[Fig] EC 3.1.3.3 : 3-Phosphoserine + H2O = L-Serine + Orthophosphate
[Fig] EC 2.7.1.80 : Diphosphate + L-Serine = Orthophosphate + 3-Phosphoserine
[Fig] EC 2.6.1.51 : L-Serine + 2-Oxopropanoate = Hydroxypyruvate + L-Alanine
[Fig] EC 2.3.1.30 : L-Serine + Acetyl-CoA = O-Acetyl-L-serine + CoA
[Fig] EC 2.6.1.45 : L-Serine + Glyoxalate = Hydroxypyruvate + Glycine
[Fig] EC 5.1.1.10 : L-Serine = D-Serine
[Fig] EC 4.2.1.22 : L-Serine + Sulfide = L-Cysteine + H2O
[Fig] EC 4.2.1.20 : L-Serine + 2,3-Benzopyrrole = L-Tryptophan + H2O

GREP v1.0.2 http://bisscat.org/GREP/
Developed by Masaaki Kotera (2008), Department of Biochemistry, Trinity College Dublin.
Science Foundation of Ireland is gratefully acknowledged.